Development of functional and structural connectivity within the default mode network in young children.
Development of functional and structural connectivity within the default mode network in young children.
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DOI：
10.1016/j.neuroimage.2010.04.009
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发表时间：
2010-08-01
期刊：
影响因子：
5.7
通讯作者：
Menon, Vinod
中科院分区：
文献类型：
--
作者：
Supekar, Kaustubh;Uddin, Lucina Q.;Prater, Katherine;Amin, Hitha;Greicius, Michael D.;Menon, Vinod
关键词：
由离散区域组成的网络的功能和结构的成熟是大脑发育的一个重要方面。默认模式网络(DMN)是一个由后扣带回(PCC)、内侧前额叶(MPFC)、内侧颞叶(MTL)和角回(AG)组成的重要网络。尽管人们对DMN的功能越来越感兴趣，但对其从童年到成年的成熟过程知之甚少。在这里，我们使用多模式成像方法结合静息状态功能磁共振成像、基于体素的形态测量和基于扩散张量成像的纤维束成像来检查DMN连通性的发育变化。我们发现，DMN在功能和结构连接方面经历了显著的发育变化，但这些变化在所有DMN节点上并不是一致的。汇聚的结构和功能连接分析表明，扣带束上的PCC-mPFC连接是儿童DMN中最不成熟的连接。PCC和mPFC也显示出灰质体积的差异，以及连接这些区域的背侧扣带束的宏观和微观结构的显著差异。值得注意的是，儿童PCC和左侧MTL之间的结构连接要么很弱，要么根本不存在，尽管功能连接与成人没有什么不同。这些结果表明，儿童的功能连接可以达到成人的水平，尽管结构连接很弱。我们认为，PCC-mPFC结构连接的成熟在青春期出现的自我相关和社会认知功能的发展中起着重要作用。更广泛地说，我们的研究展示了解剖学和连接性的定量多模分析如何使我们能够更好地描述大脑网络的异质发展和成熟。
Functional and structural maturation of networks comprised of discrete regions is an important aspect of brain development. The default-mode network (DMN) is a prominent network which includes the posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC), medial temporal lobes (MTL), and angular gyrus (AG). Despite increasing interest in DMN function, little is known about its maturation from childhood to adulthood. Here we examine developmental changes in DMN connectivity using a multimodal imaging approach by combining resting-state fMRI, voxel-based morphometry and diffusion tensor imaging-based tractography. We found that the DMN undergoes significant developmental changes in functional and structural connectivity, but these changes are not uniform across all DMN nodes. Convergent structural and functional connectivity analyses suggest that PCC-mPFC connectivity along the cingulum bundle is the most immature link in the DMN of children. Both PCC and mPFC also showed gray matter volume differences, as well as prominent macrostructural and microstructural differences in the dorsal cingulum bundle linking these regions. Notably, structural connectivity between PCC and left MTL was either weak or non-existent in children, even though functional connectivity did not differ from that of adults. These results imply that functional connectivity in children can reach adult-like levels despite weak structural connectivity. We propose that maturation of PCC-mPFC structural connectivity plays an important role in the development of self-related and social-cognitive functions that emerge during adolescence. More generally, our study demonstrates how quantitative multimodal analysis of anatomy and connectivity allows us to better characterize the heterogeneous development and maturation of brain networks.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
2
作者：
De Luca, M;Smith, S;Matthews, PM
通讯作者：
Matthews, PM
DOI：
10.1073/pnas.0601417103
发表时间：
2006-09-12
影响因子：
11.1
作者：
Damoiseaux, J. S.;Rombouts, S. A. R. B.;Beckmann, C. F.
通讯作者：
Beckmann, C. F.
影响因子：
5.7
作者：
Good, CD;Johnsrude, IS;Frackowiak, RSJ
通讯作者：
Frackowiak, RSJ