Disturbed sleep is associated with increased C-reactive protein in young women.
Disturbed sleep is associated with increased C-reactive protein in young women.
复制标题
DOI：
10.1016/j.bbi.2008.10.008
复制
发表时间：
2009-03
影响因子：
15.1
通讯作者：
Hall, Martica
中科院分区：
文献类型：
--
作者：
Okun, Michele L.;Coussons-Read, Mary;Hall, Martica
有证据表明，睡眠紊乱与过度的炎症反应有关，并增加了不良健康后果的风险。许多不良健康结果的一个新出现的风险因素是慢性低度炎症。过度的炎症反应可能在睡眠紊乱和不良健康结果之间提供生物学联系。睡眠与慢性低度炎症之间的关系在其他健康的年轻女性中很少被研究。我们评估了自我报告的睡眠和三种炎症标志物之间的横截面关系。参与者为居住在社区的非妊娠女性（N = 43，28.2 ± 5.2岁）。测量指标包括匹兹堡睡眠质量指数（PSQI）、睡眠日记和血清IL-6、TNF-α和C反应蛋白水平。在控制协变量后，睡眠质量差和连续性与较高的CRP水平相关。PSQI评分与IL-6或TNF-α之间未观察到显著相关性;睡眠时间与任何炎症标志物均无关。在年轻的成年人中，睡眠不足可能会导致慢性，低度炎症，与未来不良健康结果的风险增加有关。未来的工作应纵向评估这些关系可能会影响发展的性别特异性疾病在明显健康的年轻女性。
Evidence links disturbed sleep with an exaggerated inflammatory response and increased risk of adverse health outcomes. An emerging risk factor for many adverse health outcomes is chronic, low-grade inflammation. An exaggerated inflammatory response could provide a biological link between disturbed sleep and adverse health outcomes. The relationship between sleep and chronic, low-grade inflammation has been sparsely examined in otherwise healthy, young women. We evaluated cross-sectional relationships between self-reported sleep and three inflammatory markers. Participants were community dwelling nonpregnant women (N = 43, 28.2 ± 5.2 years of age). Measures included the Pittsburgh Sleep Quality Index (PSQI), sleep diaries, and serum levels of IL-6, TNF-α and C-reactive protein. Poor sleep quality and continuity were associated with higher CRP levels after controlling for covariates. No significant relationships were observed between PSQI scores and IL-6 or TNF-α; sleep duration was not related to any of the inflammatory markers. Poor sleep, in young adulthood, may contribute to the chronic, low-grade inflammation associated with an increased risk for future adverse health outcomes. Future work should longitudinally evaluate how these relationships may affect development of gender-specific diseases in apparently healthy young women.
登录
查看更多内容
影响因子：
4.2
作者：
Maier, B;Laurer, HL;Marzi, I
通讯作者：
Marzi, I
影响因子：
5.6
作者：
Mills, Paul J.;von Kaenel, Roland;Dimsdale, Joel E.
通讯作者：
Dimsdale, Joel E.
影响因子：
3.3
作者：
McDade, Thomas W.;Hawkley, Louise C.;Cacioppo, John T.
通讯作者：
Cacioppo, John T.
影响因子：
5.6
作者：
LEE, KA
通讯作者：
LEE, KA
DOI：
10.1111/j.1365-2362.2006.01712.x
发表时间：
2006-10-01
影响因子：
5.5
作者：
Diamanti-Kandarakis, E.;Alexandraki, K.;Panidis, D.
通讯作者：
Panidis, D.