Resting state connectivity dynamics in individuals at risk for psychosis.
Resting state connectivity dynamics in individuals at risk for psychosis.
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DOI：
10.1037/abn0000330
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发表时间：
2018-04
影响因子：
4.6
通讯作者：
Mittal VA
中科院分区：
文献类型：
--
作者：
Pelletier-Baldelli A;Andrews-Hanna JR;Mittal VA
澄清精神病风险青年（称为临床高风险）的静息状态连接的动态波动可能会告知我们对精神障碍的理解，如精神分裂症，这与连接障碍和异常的显着性处理有关。动态功能连接（DFC）研究提供了神经网络如何随着时间的推移交换信息的见解。目前，还没有发表的涉及青少年的DFC研究。这是值得注意的，因为了解网络如何随着时间的推移聚集在一起和分离可以深入了解精神病发展和精神病学的神经通信。采用滑动窗口分析法对31名青少年和28名对照者的静息扫描DFC（定义为一系列滑动窗口的SD）进行了检查。在基线和12个月后进行临床评估。相对于对照组，青少年在涉及SN和DMN区域与涉及感觉、运动、注意和内部认知功能的区域的连接中表现出较少的DFC（较低的SD）。在青春期，这种模式与12个月后更大的阳性症状相关，可能反映了异常突出处理背后的机制。较高的SN-DMN网络间DFC与青少年的基线阴性症状、焦虑和抑郁升高相关，这可能表明焦虑和沉思背后的神经过程。总的来说，通过突出独特的DFC属性在青少年和检测信息与临床相关的精神病学的联系，结果支持连接障碍和异常的显着性处理模型的精神病。
Clarifying dynamic fluctuations in resting-state connectivity in youth at risk for psychosis (termed clinical high-risk; CHR) may inform our understanding of psychotic disorders, such as schizophrenia, which have been associated with dysconnectivity and aberrant salience processing. Dynamic functional connectivity (DFC) investigations provide insight into how neural networks exchange information over time. Currently, there are no published DFC studies involving CHR youth. This is notable, as understanding how networks may come together and disassociate over time could lend insight into the neural communication that underlies psychosis development and symptomatology. A sliding-window analysis was utilized to examine DFC (defined as the SD over a series of sliding windows) in resting-state scans in a total of 31 CHR youth and 28 controls. Clinical assessments at baseline and 12-months later were conducted. CHR youth exhibited less DFC (lower SD) in connectivity involving areas of both the SN and DMN with regions involved in sensory, motor, attention, and internal cognitive functions relative to controls. Within CHR youth, this pattern was associated with greater positive symptoms 12 months later, possibly reflecting a mechanism behind aberrant salience processing. Higher SN – DMN inter-network DFC related to elevated baseline negative symptoms, anxiety and depression in CHR youth, which may indicate neurological processes underlying worry and rumination. Overall, through highlighting unique DFC properties within CHR youth and detecting informative links with clinically relevant symptomatology, results support dysconnectivity and aberrant salience processing models of psychosis.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.5
作者：
Dodell-Feder D;Delisi LE;Hooker CI
通讯作者：
Hooker CI
DOI：
10.1177/1073858411403316
发表时间：
2012-06
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Andrews-Hanna JR
通讯作者：
Andrews-Hanna JR
显着网络内和显着网络间功能连接的减少与青少年的特质焦虑有关
影响因子：
3
作者：
Geng H;Li X;Chen J;Li X;Gu R
通讯作者：
Gu R
影响因子：
2.5
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.