Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study.
Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study.
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DOI：
10.1186/ar1193
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发表时间：
2004
影响因子：
4.9
通讯作者：
Shindo H
中科院分区：
文献类型：
--
作者：
Yoshihara Y;Tsukazaki T;Osaki M;Nakashima M;Hasui K;Shindo H
人类T细胞白血病病毒I型（HTLV-I）是已知参与迟发性慢性多关节炎HTLV-I相关关节病。然而，HTLV-I感染是否能改变骨关节炎（OA）的病理生理尚不清楚。在这项研究中，我们比较了22名htlv - 1携带者和58名对照非携带者OA患者滑液（SF）样本中的几种炎症细胞因子，如c -末端甲状旁腺激素相关肽（C-PTHrP）、可溶性白介素-2受体（sIL-2R）和白介素(IL)-6，以及骨破坏标志物脱氧吡啶啉。这些患者均经临床和影像学诊断为单侧或双侧膝关节原发OA，年龄、性别和临床症状相似。我们还对来自携带者的8个滑膜组织进行了htlv - i衍生的Tax蛋白的组织病理学检查和免疫组织化学。HTLV-I携带者SF中C-PTHrP的浓度（287±280 pM）明显高于非携带者（69±34 pM），其中13名携带者高于OA的上限值。HTLV-I携带者血清sIL-2R（741±530 IU/ml）、IL-6（55±86 ng/ml）和脱氧吡啶啉（3.1±1.8 nM）浓度均高于非携带者（299±303、2.5±4.0、0.96±1.0），且与C-PTHrP呈正相关。抗htlv - 1抗原的IgM抗体阳性SF中C-PTHrP、sIL-2R和IL-6的浓度高于IgM阴性SF。组织学上，5例和2例滑膜分别表现为轻度和中度滑膜增生，伴有或不伴有一定程度的炎症反应，不能与OA区分。在所有样本中，滑膜细胞呈税收阳性，但分布较少，且经常出现在活跃增殖区域。我们的研究结果表明，尽管HTLV-I感染并不一定会使临床结果和局部滑膜炎恶化，但该病毒可以通过增加一部分携带者患者的炎症活性来潜在地改变OA的病理生理，特别是那些具有IgM抗体的患者。需要进行纵向研究来评估HTLV-I感染与OA之间的关系。
Human T cell leukaemia virus type I (HTLV-I) is known to be involved in late-onset chronic polyarthritis as HTLV-I-associated arthropathy. However, it is unclear whether HTLV-I infection could modify the pathophysiology of osteoarthritis (OA). In this study we compared several inflammatory cytokines, such as C-terminal parathyroid hormone-related peptide (C-PTHrP), soluble interleukin-2 receptor (sIL-2R) and interleukin (IL)-6, and an osteo-destruction marker, deoxypyridinoline, in synovial fluid (SF) samples obtained from 22 HTLV-I carriers and 58 control non-carrier patients with OA. These patients were diagnosed clinically and radiographically with primary OA affecting one or both knee joints, and were similar with regard to age, sex and clinical symptoms. We also performed histopathological examination as well as immunohistochemistry of HTLV-I-derived Tax protein in eight synovial tissues taken from carrier patients. C-PTHrP in SF was significantly higher in HTLV-I carriers (287 ± 280 pM) than in non-carriers (69 ± 34 pM), and the concentration in 13 carriers was above the upper range of OA. In HTLV-I carriers, the concentrations of sIL-2R (741 ± 530 IU/ml), IL-6 (55 ± 86 ng/ml) and deoxypyridinoline (3.1 ± 1.8 nM) were higher than in non-carriers (299 ± 303, 2.5 ± 4.0, 0.96 ± 1.0, respectively), and correlated positively with C-PTHrP. C-PTHrP, sIL-2R and IL-6 concentrations in SF positive for IgM antibody against HTLV-I antigen, a marker of persistent viral replication, were higher than of IgM-negative SF. Histologically, five and two synovia showed mild and moderate synovial proliferation with or without some degree of inflammatory reaction, respectively, and could not be distinguished from OA. Tax-positive synoviocytes were observed sparsely in all samples, and often appeared frequently in actively proliferating regions. Our results suggest that although HTLV-I infection does not necessarily worsen the clinical outcome and local synovitis, the virus can potentially modify the pathophysiology of OA by increasing the inflammatory activity in a subset of carrier patients, especially those with IgM antibody. Longitudinal studies are required to assess the association between HTLV-I infection and OA.
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影响因子：
2.2
作者：
LEE, B;TANAKA, Y;TOZAWA, H
通讯作者：
TOZAWA, H
影响因子：
15.9
作者：
MANSSON, B;CAREY, D;SAXNE, T
通讯作者：
SAXNE, T
DOI：
10.1073/pnas.78.10.6476
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
HINUMA, Y;NAGATA, K;MIYOSHI, I
通讯作者：
MIYOSHI, I
影响因子：
4
作者：
Muller, A;Hein, G;Stein, G
通讯作者：
Stein, G
影响因子：
3.4
作者：
Sebastian, D;Nayiager, S;Mody, GM
通讯作者：
Mody, GM