Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: the effect on cognitive functioning.
Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: the effect on cognitive functioning.
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DOI：
10.1016/j.pnpbp.2011.01.005
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发表时间：
2011-03-30
影响因子：
5.6
通讯作者：
Luis Vazquez-Barquero, Jose
中科院分区：
文献类型：
--
作者：
Crespo-Facorro, Benedicto;Roiz-Santianez, Roberto;Perez-Iglesias, Rocio;Mata, Ignacio;Manuel Rodriguez-Sanchez, Jose;Tordesillas-Gutierrez, Diana;Ortiz-Garcia de la Foz, Victor;Tabares-Seisdedos, Rafael;Sanchez, Elena;Andreasen, Nancy;Magnotta, Vicent;Luis Vazquez-Barquero, Jose
之前的研究已经揭示了不同性别在大脑形态测量上的差异。性别对皮质厚度的影响可能正在影响性别之间的认知差异。通过这项探索性研究，我们旨在调查基于MRI的健康年轻志愿者大脑皮层形态测量中性别的影响，以及皮质测量的可变性如何影响男性和女性的认知功能。76名年轻健康志愿者(男45名，女31名)接受了1.5T磁共振扫描，其中53人完成了综合认知成套检查。总体而言，皮质层厚度、表面积和曲率指数在性别之间没有显著差异。然而，大脑半球交互作用对总皮质厚度有显著影响(F(1，72)=5.02；p=0.03)。男性的皮质厚度有更大的向左不对称。只有女性表现出皮质厚度和认知功能(智商和执行功能)之间的显著关联。总而言之，我们的发现不支持皮质地幔形态中性二型性的概念。结果还表明，皮质厚度的变化可能会影响女性的认知功能，但不会影响男性的认知功能。
Previous investigations have revealed sex-specific differences in brain morphometry. The effect of sex on cortical thickness may be influencing cognitive differences between sexes. With this exploratory study, we aimed to investigate the effect of sex in MRI-based cerebral cortex morphometry in healthy young volunteers and how the variability in cortical measures might affect cognitive functioning in men and women. 76 young healthy volunteers (45 men and 31 women) underwent a 1.5 T MR scan and 53 of them completed a comprehensive cognitive battery. Overall no gross significant differences between sexes were found in cortical thickness, surface area and curvature indexes. However, there was a significant group by hemisphere interaction in the total cortical thickness (F(1,72)=5.02; p=0.03). A greater leftward asymmetry was observed in cortical thickness in males. Only females show significant associations between cortical thickness and cognitive functioning (IQ and executive functioning). In conclusion, our findings do not support the notion of sexual dimorphism in cortical mantle morphology. The results also suggest that variability in cortical thickness may affect cognitive functioning in females but not in males.
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影响因子：
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作者：
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通讯作者：
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