High prevalence of maternal vitamin D deficiency in preterm births in northeast China, Shenyang.
High prevalence of maternal vitamin D deficiency in preterm births in northeast China, Shenyang.
复制标题
中国东北沉阳地区孕产妇维生素 D 缺乏症早产率较高。
DOI：
--
复制
发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Zhao Qun
中科院分区：
文献类型：
--
作者：
Ge Xin;Kong Juan;Zhang Lijun;Zhao Qun
介绍
母亲维生素D缺乏与许多胎儿和新生儿健康问题有关。早产是最有害的，母亲维生素D缺乏在早产中的作用尚未得到普遍承认。关于中国人群维生素D缺乏症的流行病学研究有限。
受试者和方法
2012年1月1日至2013年1月1日在中国医科大学附属盛京医院分娩的产妇1103例。最后，收集了821对母婴对，其中包括143对早产的母婴对进行分析。
结果
春季与夏季、春季与秋季之间差异均有显著性（P <0.0001）。25（OH）D水平冬季显著低于夏季和秋季（夏冬P<0.0001，秋冬P<0.0001）。母亲维生素D水平随月份和季节变化明显，夏季较高，冬季较低。极早产组与轻度早产组、足月早产组维生素D水平差异有显著性（P <0.001）。极早产组孕妇维生素D缺乏率为63.04%，足月组为36.61%。
结论
沈阳市孕妇及新生儿维生素D营养状况与同纬度城市相比相对较好。维生素D缺乏在晚春最严重，夏季最少。妊娠31周前的严重早产与母亲维生素D缺乏有关。
INTRODUCTION
Maternal vitamin D deficiency has been associated with a number of fetal and neonatal health problems. Preterm birth is one of the most detrimental, and the role of maternal vitamin D deficiency in preterm births has not been universally acknowledged. There had been limited epidemiological studies of vitamin D deficiency on the Chinese population.
SUBJECTS AND METHODS
1103 women delivered in Shengjing Hospital, China Medical University from January 1(st), 2012 to January 1(st), 2013. Finally, 821 mother-newborn pairs which contained 143 mother-newborn pairs who were preterm delivery were recruited for analysis.
RESULTS
There was significant difference between spring and summer (P<0.0001) as well as spring and autumn (P<0.01). Compared to those in summer and autumn, the 25 (OH) D level was significantly lower in winter (summer vs winter P<0.0001, autumn vs winter P<0.0001). Maternal vitamin D level showed obvious variation with months and seasons, with higher level in summer months and lower level in winter months. There were significant difference between the vitamin D level of the very preterm group and the mildly preterm groups (P<0.01), as well as the very preterm group and the in-term groups (P<0.001). Prevalence of Vitamin D deficiency occurred in 63.04% of pregnant women in very preterm group, compared with 36.61% in in-term group.
CONCLUSION
Vitamin D nutritional status of pregnant women and their newborns in Shenyang were relatively good compared to cities in similar latitudes. Vitamin D deficiency was most severe in late spring and least in summer. Severe preterm births before 31 weeks of gestation was associated with maternal vitamin D deficiency.
登录
查看更多内容
影响因子：
7.7
作者：
Baydas, G;Karatas, F;Canatan, H
通讯作者：
Canatan, H
DOI：
10.1093/ajcn/84.1.350
发表时间：
2006-08
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
I. M. van der Meer;N. S. Karamali;A. Boeke;P. Lips;B. Middelkoop;I. Verhoeven;J. D. Wuister
通讯作者：
I. M. van der Meer;N. S. Karamali;A. Boeke;P. Lips;B. Middelkoop;I. Verhoeven;J. D. Wuister
DOI：
10.1093/ajcn/79.5.717
发表时间：
2004-05
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
B. Hollis;C. Wagner
通讯作者：
B. Hollis;C. Wagner
影响因子：
3.9
作者：
Chen, Tai C.;Chimeh, Farhad;Holick, Michael F.
通讯作者：
Holick, Michael F.
影响因子：
7.1
作者：
Baker, Philip N.;Wheeler, Simon J.;Poston, Lucilla
通讯作者：
Poston, Lucilla