Cognitive function in early and later life is associated with blood glucose in older individuals: analysis of the Lothian Birth Cohort of 1936.
Cognitive function in early and later life is associated with blood glucose in older individuals: analysis of the Lothian Birth Cohort of 1936.
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DOI：
10.1007/s00125-018-4645-8
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发表时间：
2018-09
期刊：
影响因子：
8.2
通讯作者：
Deary IJ
中科院分区：
文献类型：
--
作者：
Altschul DM;Starr JM;Deary IJ
本研究的目的是研究早期和晚期生活的认知功能，以及70岁至79岁认知功能的下降是否与基线（70岁）时HbA1c测量的高血糖和70岁至79岁的血糖变化有关。对1936年洛锡安出生队列中的参与者（n = 1091）进行了检查。14项测试用于评估认知功能，分为四个领域：视觉空间能力、处理速度、记忆力和结晶能力。在平均年龄为70岁、73岁、76岁和79岁的四次评估中，分别收集测试结果、HbA1c和其他健康变量的测量值。该队列11岁时的认知功能数据也可获得。进行了潜在生长曲线建模，并引入了已知危险因素的统计控制。11岁认知功能越高，70岁时HbA1c水平越低（p < 0.001）。70岁时较高的认知功能与70岁至79岁期间HbA1c水平相对较小的升高相关（p < 0.001）。70 - 79岁的HbA1c与70 - 79岁的认知功能变化没有任何一致的关联。这些相关性在年龄、性别、教育程度、APOE*ε4、吸烟史、心血管病史、高血压史、BMI和多重测试校正后仍然存在。我们的研究结果表明，在老年人中，高血糖与认知功能低下一致。检查和跟踪认知功能的临床护理，同时也考虑到维持认知功能的积极作用，并模仿与更高认知功能相关的健康行为，可能是保护高危个体免受血糖升高和随后的2型糖尿病的一种方法。本文的在线版本（10.1007/s00125-018-4645-8）包含同行评审但未经编辑的补充材料，授权用户可使用。
The aim of this study was to examine whether cognitive function in early and later life, and decline in cognitive function from age 70 to 79 years, are associated with high blood glucose, as measured by HbA1c, at baseline (age 70), and changes in blood glucose from age 70 to 79. Participants (n = 1091) in the Lothian Birth Cohort of 1936 were examined. Fourteen tests were used to assess cognitive functions, grouped into four domains: visuospatial ability, processing speed, memory and crystallised ability. Test results, and measurements of HbA1c and other health variables, were collected at each of four waves of assessment: at the mean age of 70, 73, 76 and 79 years. Data on cognitive function at age 11 was also available for this cohort. Latent growth curve modelling was performed and statistical controls for known risk factors were introduced. Higher age 11 cognitive function predicted lower HbA1c level at age 70 (p < 0.001). Higher cognitive function at age 70 was related to a comparatively smaller increase in HbA1c levels from age 70 to 79 (p < 0.001). HbA1c from age 70 to 79 did not have any consistent association with change in cognitive function from age 70 to 79. These associations survived adjustments for age, sex, education, APOE*ε4, smoking history, cardiovascular disease history, hypertension history, BMI and corrections for multiple testing. Our results show that, among older individuals, high blood glucose is consistently predicted by lower cognitive function. Clinical care that examines and tracks cognitive function, while also taking the positive effects of maintaining cognitive function and emulating healthy behaviours associated with higher cognitive function into account, may be one approach for protecting at-risk individuals from elevated blood glucose and subsequent type 2 diabetes mellitus. The online version of this article (10.1007/s00125-018-4645-8) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
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影响因子：
4.1
作者：
Deary IJ;Gow AJ;Taylor MD;Corley J;Brett C;Wilson V;Campbell H;Whalley LJ;Visscher PM;Porteous DJ;Starr JM
通讯作者：
Starr JM
影响因子：
5.7
作者：
Deary, IJ;Simonotto, E;Wardlaw, JM
通讯作者：
Wardlaw, JM
影响因子：
4.7
作者：
Čukić I;Mõttus R;Luciano M;Starr JM;Weiss A;Deary IJ
通讯作者：
Deary IJ
影响因子：
3.7
作者：
Deary, Ian J.;Johnson, Wendy;Starr, John M.
通讯作者：
Starr, John M.
影响因子：
168.9
作者：
McCrimmon, Rory J.;Ryan, Christopher M.;Frier, Brian M.
通讯作者：
Frier, Brian M.