Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications.
Cell type-dependent biomarker expression in adenoid cystic carcinoma: biologic and therapeutic implications.
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DOI：
10.1002/cncr.25541
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发表时间：
2010-12-15
期刊：
影响因子：
6.2
通讯作者：
El-Naggar, Adel K.
中科院分区：
文献类型：
--
作者：
Bell, Diana;Roberts, Dianna;Kies, Merrill;Rao, Pulivarthi;Weber, Randal S.;El-Naggar, Adel K.
腺样囊性癌是一种罕见的进行性涎腺恶性肿瘤，具有细胞、形态和临床异质性。我们推测其双重细胞组成在生物标志物评价、肿瘤生物学行为和治疗反应中起重要作用。为了研究c-kit和EGFR蛋白的差异定位和表达，我们对199例肿瘤组织芯片进行了免疫组化分析，并将结果与临床病理因素相关联。结果表明，c-kit的表达仅限于内导管上皮细胞和EGFR的表达主要是外肌上皮细胞中的大多数管状和筛状模式。在实性ACC中，c-kit一致阳性，而EGFR一致阴性。c-Kit表达与3年预后差，EGFR表达与3年预后好之间存在显著的统计学相关性。我们的研究结果强调了细胞亚型的生物标志物定位在该实体患者的临床和治疗分层中的重要性。
Adenoid cystic carcinoma (ACC), a rare and progressive salivary malignancy, is characterized by cellular, morphologic and clinical heterogeneity. We hypothesize that its dual cellular composition plays an important role in biomarker evaluation, tumor biological behavior and therapy response. To investigate the differential localization and expression of c-kit and EGFR proteins, we performed immunohistochemical analysis on tissue arrays of 199 tumors and correlated the results with the clinico-pathological factors. The results show c-kit expression to be limited to the inner ductal epithelial cells and the EGFR expression mainly to the outer myoepithelial cells in the majority of tubular and cribriform patterns. In solid ACC, c-kit was uniformly positive while EGFR was consistently negative. Significant statistical correlation was found between c-Kit expression and a poor 3- year outcome, and EGFR expression with a better 3-year outcome. Our findings underscore the importance of cellular subtypes’ localization of biomarkers in the clinical and therapeutic stratification of patients with this entity.
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影响因子：
9.7
作者：
Jeng, YM;Lin, CY;Hsu, HC
通讯作者：
Hsu, HC
DOI：
10.1067/moe.2003.31
发表时间：
2003-05-01
影响因子：
--
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Miller, FR
影响因子：
1
作者：
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通讯作者：
Lenarz, T
影响因子：
7.3
作者：
Pan, CC;Chen, PCH;Chiang, H
通讯作者：
Chiang, H