The child as proband for future parental cardiometabolic disease: the 26-year prospective Princeton Lipid Research Clinics Follow-up Study.
The child as proband for future parental cardiometabolic disease: the 26-year prospective Princeton Lipid Research Clinics Follow-up Study.
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孩子作为未来父母心脏代谢疾病的先证者：26 年前瞻性普林斯顿脂质研究诊所随访研究。
DOI：
10.1016/j.jpeds.2011.12.003
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Wang,Ping
中科院分区：
文献类型：
--
作者：
Morrison,JohnA;Glueck,CharlesJ;Wang,Ping
为了评估儿童心血管疾病（CVD）的危险因素作为父母随后发生CVD、2型糖尿病（T2 DM）和高血压（HBP）的预测因子，我们对852名5- 19岁的黑人和白色学生进行了26年的前瞻性随访（平均年龄，12岁; Lipid Research Clinics，1973-8），和来自俄亥俄州辛辛那提普林斯顿学校的519个家庭的父母（平均年龄，40岁）。1999-2003年普林斯顿随访研究中，对平均年龄为39岁的学龄儿童进行了重新评估;对1038名父母的CVD、T2 DM和HBP病史进行了重新评估，平均年龄为66岁。我们评估了儿童期危险因素与父母CVD、T2 DM和HBP的关系。儿童先证者的甘油三酯（TG）水平、血压、低密度脂蛋白胆固醇水平、体重指数（BMI）、血糖水平高于和高密度脂蛋白胆固醇水平低于确定的临界点。儿童HBP（P= 0.006）和低高密度脂蛋白胆固醇（P= 0.018）可预测年龄≤50岁的父母CVD。儿童HBP（P= 0.02）和高TG（P= 0.03）可预测年龄≤60岁的父母CVD。儿童高TG（P= 0.009）和高低密度脂蛋白胆固醇（P= 0.04）可预测66岁时父母CVD。儿童高BMI（P= 0.0006）可预测父母T2 DM。儿童高BMI（P=.003）和黑人种族（P=.004）预测父母HBP.CONCLUSIONSPediatric风险因素确定家庭与父母在增加风险的CVD，T2 DM，和HBP，强调有用的孩子作为先证者。
OBJECTIVETo evaluate children’s cardiovascular disease (CVD) risk factors as predictors of parents’ subsequent CVD, type 2 diabetes mellitus (T2DM), and high blood pressure (HBP).STUDY DESIGNWe conducted a 26-year prospective follow-up of 852 5- to 19-year-old black and white schoolchildren (mean age, 12 years; Lipid Research Clinics, 1973-8), and parents (mean age, 40 years) from 519 families in Princeton Schools, Cincinnati, Ohio. Schoolchildren were reassessed in the Princeton Follow-up study 1999-2003 at mean age 39 years; CVD, T2DM, and HBP history of their 1038 parents were reassessed by mean age 66 years. We assessed relationships of childhood risk factors with parental CVD, T2DM, and HBP. Child-probands identified with triglyceride (TG) levels, blood pressure, low-density lipoprotein cholesterol levels, body mass index (BMI), and glucose level greater than and high-density lipoprotein cholesterol levels less than established cutoff points.RESULTSPediatric HBP (P=.006) and low high-density lipoprotein cholesterol (P=.018) were predictive of parental CVD at age ≤50 years. Pediatric HBP (P=.02) and high TG (P=.03) were predictive of parental CVD at age ≤60 years. Pediatric high TG (P=.009) and high low-density lipoprotein cholesterol (P=.04) were predictive of parental CVD by age 66 years. Pediatric high BMI (P=.0006) were predictive of parental T2DM. Pediatric high BMI (P=.003) and black race (P=.004) were predictive of parental HBP.CONCLUSIONSPediatric risk factors identify families with parents at increased risk for CVD, T2DM, and HBP, emphasizing the usefulness of the child as proband.
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