Comorbidity between major depression and alcohol use disorder from adolescence to adulthood.
Comorbidity between major depression and alcohol use disorder from adolescence to adulthood.
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DOI：
10.1016/j.comppsych.2013.10.007
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发表时间：
2014-04
影响因子：
7.3
通讯作者：
Lewinsohn PM
中科院分区：
文献类型：
--
作者：
Brière FN;Rohde P;Seeley JR;Klein D;Lewinsohn PM
关于重度抑郁症 (MDD) 和酒精使用障碍 (AUD；滥用/依赖) 之间合并症的长期发展的信息有限。通过一项具有代表性的前瞻性研究，我们检查了与 MDD+AUD 合并症相关的多个方面，重点关注不同时期（青春期、成年早期、成年期）的疾病与 30 岁时累积损伤之间的关系。816 名参与者在 16、17、24 和 30 岁接受了诊断性访谈。MDD+AUD 合并症的发生率在青春期较低 (2%)，但在成年早期有所增加(10%) 和成年期 (7%)。累积合并症发生率升高（21%）。大多数有 MDD 或 AUD 病史的人都患有另一种疾病，但患有 MDD 的女性除外。前瞻性地，青少年 AUD 预测早期成人 MDD，而早期成人 MDD 预测成人 AUD。与纯粹的疾病相比，MDD+AUD 与酒精依赖、自杀企图、整体功能较低和生活不满意的风险较高相关。共病 MDD+AUD 的终生发生率明显高于横断面研究。合并症的部分解释是双向的和发育特异性的关联，并预测了选择性的而不是普遍的损害。在临床上，我们的研究结果强调需要始终仔细评估 MDD 或 AUD 患者的合并症，同时考虑并发性和发育时间。
Limited information exists regarding the long-term development of comorbidity between Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD; abuse/dependence). Using a representative prospective study, we examine multiple aspects pertaining to MDD+AUD comorbidity, with a focus on the relation between disorders across periods (adolescence, early adulthood, adulthood) and cumulative impairments by age 30. 816 participants were diagnostically interviewed at ages 16, 17, 24, and 30. Rates of comorbid MDD+AUD were low in adolescence (2%), but increased in early adulthood (10%) and adulthood (7%). Rates of cumulative comorbidity were elevated (21%). Most individuals with a history of MDD or AUD had the other disorder, except for women with MDD. Prospectively, adolescent AUD predicted early adult MDD, while early adult MDD predicted adult AUD. Compared to pure disorders, MDD+AUD was associated with higher risk of alcohol dependence, suicide attempt, lower global functioning, and life dissatisfaction. Lifetime rates of comorbid MDD+AUD were considerably higher than in cross-sectional studies. Comorbidity was partly explained by bidirectional and developmentally-specific associations and predicted selected rather than generalized impairments. Clinically, our findings emphasize the need to always carefully assess comorbidity in patients with MDD or AUD, taking into account concurrency and developmental timing.
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影响因子：
6.6
作者：
Boschloo, Lynn;Vogelzangs, Nicole;Penninx, Brenda W. J. H.
通讯作者：
Penninx, Brenda W. J. H.
影响因子：
7.4
作者：
Bulloch, Andrew;Lavorato, Dina;Patten, Scott
通讯作者：
Patten, Scott
影响因子：
6.6
作者：
Grant, BF;Hasin, DS;Dawson, DA
通讯作者：
Dawson, DA
影响因子：
4.4
作者：
Merikangas, KR;Mehta, RL;Kessler, RC
通讯作者：
Kessler, RC
DOI：
10.15288/jsa.1998.59.97
发表时间：
1998-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Dawson, DA;Grant, BF
通讯作者：
Grant, BF