Isolation and characterization of three mammalian orthoreoviruses from European bats.
Isolation and characterization of three mammalian orthoreoviruses from European bats.
复制标题
DOI：
10.1371/journal.pone.0043106
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kurth A
中科院分区：
文献类型：
--
作者：
Kohl C;Lesnik R;Brinkmann A;Ebinger A;Radonić A;Nitsche A;Mühldorfer K;Wibbelt G;Kurth A
近年来，在东南亚和澳大利亚发现了新的人类呼吸道疾病病原体。病原分类为翼鸟正呼肠病毒，与居住在这些地区的狐蝠正呼肠病毒有较强的系统发育关系。随后，假定人畜共患的蝙蝠-人类传播。我们报告从欧洲蝙蝠中分离出三种新的哺乳动物正呼肠孤病毒（mrv），包括东南亚和澳大利亚以外的蝙蝠传播的正呼肠孤病毒，此外还在食虫蝙蝠（微翼目）中检测到。众所周知，mrv可以感染包括人类在内的多种哺乳动物。虽然它们在宿主中与相当轻微和临床不明显的感染有关，但越来越多的证据表明，它们也有能力在狗和人中引起更严重的疾病。在这项研究中，120只蝙蝠中有8只被证明感染了三种新型MRV分离株中的一种，具有明显的肠道器官倾向。其中一株经454基因组测序分析。菌株T3/Bat/Germany/342/08与MRV菌株T3D/04亲缘关系最密切。这些新型呼肠孤病毒为深入了解可能的传播事件和追踪蝙蝠病毒的进化提供了难得的机会。
In recent years novel human respiratory disease agents have been described in South East Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with strong phylogenetic relationship to orthoreoviruses of flying foxes inhabiting these regions. Subsequently, a zoonotic bat-to-human transmission has been assumed. We report the isolation of three novel mammalian orthoreoviruses (MRVs) from European bats, comprising bat-borne orthoreovirus outside of South East Asia and Australia and moreover detected in insectivorous bats (Microchiroptera). MRVs are well known to infect a broad range of mammals including man. Although they are associated with rather mild and clinically unapparent infections in their hosts, there is growing evidence of their ability to also induce more severe illness in dogs and man. In this study, eight out of 120 vespertilionid bats proved to be infected with one out of three novel MRV isolates, with a distinct organ tropism for the intestine. One isolate was analyzed by 454 genome sequencing. The obtained strain T3/Bat/Germany/342/08 had closest phylogenetic relationship to MRV strain T3D/04, isolated from a dog. These novel reoviruses provide a rare chance of gaining insight into possible transmission events and of tracing the evolution of bat viruses.
登录
查看更多内容
DOI：
10.1007/bf01249346
发表时间：
1973-01-01
期刊：
ARCHIV FUR DIE GESAMTE VIRUSFORSCHUNG
影响因子：
--
作者：
GARD, GP;MARSHALL, ID
通讯作者：
MARSHALL, ID
影响因子：
5.4
作者：
DERMODY, TS;NIBERT, ML;FIELDS, BN
通讯作者：
FIELDS, BN
影响因子：
1.6
作者：
Day, J. Michael;Pantin-Jackwood, Mary J.;Spackman, Erica
通讯作者：
Spackman, Erica
DOI：
10.1006/bbrc.2001.5612
发表时间：
2001-09-21
影响因子：
3.1
作者：
Attoui, H;Biagini, P;de Lamballerie, X
通讯作者：
de Lamballerie, X
影响因子：
3.3
作者：
Decaro N;Campolo M;Desario C;Ricci D;Camero M;Lorusso E;Elia G;Lavazza A;Martella V;Buonavoglia C
通讯作者：
Buonavoglia C