The effect of obstructed action efficacy on reward-based decision-making in healthy adolescents: a novel functional MRI task to assay frustration.
The effect of obstructed action efficacy on reward-based decision-making in healthy adolescents: a novel functional MRI task to assay frustration.
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DOI：
10.3758/s13415-021-00975-w
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发表时间：
2022-06
影响因子：
2.9
通讯作者：
Yang, Tony T.
中科院分区：
文献类型：
--
作者：
Harle, Katia M.;Ho, Tiffany C.;Connolly, Colm G.;Simmons, Alan N.;Yang, Tony T.
挫折感在青少年时期很常见，通常会干扰执行功能，特别是基于奖励的决策。然而，很少有人知道偶然的挫折事件（独立于基于任务的反馈）如何破坏这个重要年龄组的奖励处理的神经回路。在进行功能性磁共振成像（fMRI）时，45名健康的青少年玩了一个纸牌游戏，他们必须在低和高风险条件下猜测两个选项以获得积分。他们做出决定的按键功能间歇性地受阻，从而增加了挫折感。神经失活楔前叶，默认模式网络区域，观察到在整个桩条件下的行动受阻块，但相对于低风险的高试验。此外，目标导向的奖励处理区域（即，尾状核）、额顶叶“任务控制”区域，以及内感受处理区域（即，躯体感觉皮层、丘脑）的变化。这些发现与健康青少年在高风险条件下阻塞行动效能期间目标导向奖励寻求的干扰较少是一致的。这些结果提供了神经系统的路线图，这些神经系统对于青少年在基于奖励的决策过程中处理令人沮丧的事件至关重要，并且可以帮助描述挫折调节在一系列儿科精神病理学中是如何改变的。
Frustration is common in adolescence and often interferes with executive functioning, particularly reward-based decision-making. Yet, very little is known about how incidental frustrating events (independent of taskbased feedback) disrupt the neural circuitry of reward processing in this important age group. While undergoing functional magnetic resonance imaging (fMRI), 45 healthy adolescents played a card game in which they had to guess between two options to earn points, in low- and high-stake conditions. Functioning of button presses through which they made decisions was intermittently blocked, thereby increasing frustration potential. Neural deactivation of the precuneus, a Default Mode Network region, was observed during obstructed action blocks across stake conditions, but less so on high-relative to low-stake trials. Moreover, less deactivation in goal-directed reward processing regions (i.e., caudate), frontoparietal ‘task control’ regions, and interoceptive processing regions (i.e., somatosensory cortex, thalamus) were observed on high-stake relative to low-stake trials. These findings are consistent with less disruption of goal-directed reward seeking during blocked action efficacy in high-stake conditions among healthy adolescents. These results provide a roadmap of neural systems critical to the processing of frustrating events during reward-based decision-making in youths and could help characterize how frustration regulation is altered in a range of pediatric psychopathologies.
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DOI：
10.1146/annurev-clinpsy-032816-044941
发表时间：
2017-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 13
影响因子：
--
作者：
Brotman, Melissa A.;Kircanski, Katharina;Leibenluft, Ellen
通讯作者：
Leibenluft, Ellen
影响因子：
5.3
作者：
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通讯作者：
Hommer, DW
影响因子：
22.4
作者：
BERKOWITZ, L
通讯作者：
BERKOWITZ, L
影响因子：
5.8
作者：
Bava, Sunita;Tapert, Susan F.
通讯作者：
Tapert, Susan F.
DOI：
10.1176/appi.ajp.2008.07081336
发表时间：
2009-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Forbes EE;Hariri AR;Martin SL;Silk JS;Moyles DL;Fisher PM;Brown SM;Ryan ND;Birmaher B;Axelson DA;Dahl RE
通讯作者：
Dahl RE