Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior.
Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior.
复制标题
海马位置细胞的靶向激活驱动记忆引导的空间行为。
DOI：
10.1016/j.cell.2020.09.061
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发表时间：
2020-12-10
期刊：
影响因子：
64.5
通讯作者：
Häusser M
中科院分区：
文献类型：
--
作者：
Robinson NTM;Descamps LAL;Russell LE;Buchholz MO;Bicknell BA;Antonov GK;Lau JYN;Nutbrown R;Schmidt-Hieber C;Häusser M
海马体对于空间导航和情景记忆的形成至关重要。海马位置细胞在环境中表现出空间选择性活动，并已被提出形成支持这些记忆功能的空间认知地图的神经基础。然而，位置细胞活动对空间导航行为的直接影响尚未得到证实。使用同步双光子钙成像和双光子光遗传学的“全光学”组合，我们识别并选择性激活了在虚拟现实环境中编码行为相关位置的位置细胞。有针对性地刺激少量的位置细胞足以使动物在空间记忆任务中的行为发生偏差，这为海马位置细胞积极支持空间导航和记忆提供了因果证据。二--VR中的光子光遗传学实现了位置细胞集合的靶向操纵激活特定位置细胞集合驱动其空间相关行为位置细胞刺激抑制内源性位置代码表达并触发重映射位置细胞在空间导航中因果作用的直接证据选择性刺激小鼠中少量海马位置细胞提供了海马位置细胞积极支持空间定位的因果证据。导航和记忆
The hippocampus is crucial for spatial navigation and episodic memory formation. Hippocampal place cells exhibit spatially selective activity within an environment and have been proposed to form the neural basis of a cognitive map of space that supports these mnemonic functions. However, the direct influence of place cell activity on spatial navigation behavior has not yet been demonstrated. Using an ‘all-optical’ combination of simultaneous two-photon calcium imaging and two-photon optogenetics, we identified and selectively activated place cells that encoded behaviorally relevant locations in a virtual reality environment. Targeted stimulation of a small number of place cells was sufficient to bias the behavior of animals during a spatial memory task, providing causal evidence that hippocampal place cells actively support spatial navigation and memory. Two-photon optogenetics in VR enables targeted manipulation of place cell ensembles Activating specific place cell ensembles drives their spatially associated behavior Place cell stimulation inhibits endogenous place code expression and triggers remapping Direct evidence for a causal role of place cells in spatial navigation Selective stimulation of a small number of hippocampal place cells in mice provides causal evidence that hippocampal place cells actively support spatial navigation and memory.
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