Learning and memory are impaired in the object recognition task during metestrus/diestrus and after sleep deprivation.
Learning and memory are impaired in the object recognition task during metestrus/diestrus and after sleep deprivation.
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DOI：
10.1016/j.bbr.2017.11.033
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发表时间：
2018-02-26
影响因子：
2.7
通讯作者：
McCarley RW
中科院分区：
文献类型：
--
作者：
Cordeira J;Kolluru SS;Rosenblatt H;Kry J;Strecker RE;McCarley RW
女性是一个代表性不足的研究模型，睡眠不足损害认知的机制尚不清楚。由于生殖激素水平和发情周期对睡眠不足敏感，并且是学习和记忆所必需的，因此我们假设睡眠剥夺通过干扰发情周期来影响雌性小鼠的学习和记忆。我们使用物体识别任务来评估雌性小鼠在发情周期的不同阶段和睡眠丧失后的学习和记忆。小鼠在动情后期/动情间期参加样本对象比小鼠在动情前期/动情期在对象采集，对象识别任务的第一阶段。随后，在任务的识别阶段，只有处于发情期/发情期的小鼠表现出对新物体的偏好。在物体识别任务之前立即剥夺睡眠12小时，减少了发情前期/发情期小鼠对样品物体和新物体的偏好的时间，而不改变发情周期的长度。这些结果表明，睡眠剥夺小鼠在发情前期/发情期有学习缺陷和记忆障碍，像小鼠在发情后期/发情间期。然而，由于睡眠剥夺并没有破坏发情周期，结果并不支持这一假设。急性睡眠缺失导致的认知障碍不是由于发情周期的改变。
Females are an under-represented research model and the mechanisms through which sleep loss impairs cognition are not clear. Since levels of reproductive hormones and the estrous cycle are sensitive to sleep loss and necessary for learning and memory, we hypothesized that sleep deprivation impacts learning and memory in female mice by interfering with the estrous cycle. We used the object recognition task to assess learning and memory in female mice during separate phases of the estrous cycle and after sleep loss. Mice in metestrus/diestrus attended to sample objects less than mice in proestrus/estrus during object acquisition, the first phase of the object recognition task. Subsequently, during the recognition phase of the task, only mice in proestrus/estrus displayed a preference for the novel object. Sleep deprivation for 12h immediately before the object recognition task reduced time attending to sample objects and novel object preference for mice in proestrus/estrus, without changing length of the estrous cycle. These results show that sleep deprived mice in proestrus/estrus had learning deficits and memory impairments, like mice in metestrus/diestrus. Since sleep deprivation did not disrupt the estrous cycle, however, results did not support the hypothesis. Cognitive impairments due to acute sleep loss were not due to alterations to the estrous cycle.
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影响因子：
2.7
作者：
Alvarenga, Tathiana A.;Patti, Camilla L.;Tufik, Sergio
通讯作者：
Tufik, Sergio
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