Circulating microRNA-126 in patients with coronary artery disease: correlation with LDL cholesterol.
Circulating microRNA-126 in patients with coronary artery disease: correlation with LDL cholesterol.
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DOI：
10.1186/1477-9560-10-16
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发表时间：
2012-08-28
影响因子：
3.1
通讯作者：
Fujii S
中科院分区：
文献类型：
--
作者：
Sun X;Zhang M;Sanagawa A;Mori C;Ito S;Iwaki S;Satoh H;Fujii S
冠状动脉疾病（CAD）是世界范围内的主要问题。CAD的动脉粥样硬化和血栓形成涉及多种细胞类型。需要新的和有用的诊断标志物。MicroRNAs（miRNAs）是一类转录后调节基因表达的非编码RNA，参与多种细胞过程。内皮功能障碍与动脉粥样硬化血栓形成的早期过程有关。因此，假设CAD患者的血浆样品中血管内皮富集的miRNA的水平会改变。分析了31例CAD患者和36例非CAD患者血浆中血管内皮富集的miRNA（miR-126）水平（qRT-PCR分析）。miR-126在CAD患者中未显著下调或上调。有趣的是，miR-126水平在CAD和高低密度脂蛋白（LDL）胆固醇水平的患者中显著降低。相比之下，当LDL胆固醇高时，在具有CAD风险因素但没有血管造影显著CAD的患者中，miR-126水平显著增加。miR-126在CAD患者中不显著下调或上调，并且不适合区分CAD患者和非CAD患者。在有或没有CAD的患者中，miR-126和LDL胆固醇之间的反向关系可能对确定miR-126在胆固醇代谢中的潜在作用具有重要意义。
Coronary artery disease (CAD) is a major problem worldwide. Atherosclerosis and thrombosis underlying CAD involve multiple cell types. New and useful diagnostic markers are required. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the gene expressions involved in various cellular processes. Endothelial dysfunction is implicated in early processes of athero-thrombosis. Thus, it was hypothesized that the level of vascular endothelium-enriched miRNAs would be altered in plasma samples of CAD patients. Vascular endothelium-enriched miRNA (miR-126) level was analyzed in plasma from 31 patients with CAD and 36 patients without CAD (qRT-PCR analysis). MiR-126 was not significantly down-regulated or up-regulated in CAD patients. Interestingly, the level of miR-126 was significantly decreased in patients with CAD and high low-density lipoprotein (LDL) cholesterol level. In contrast, the level of miR-126 was significantly increased when LDL cholesterol was high in patients who had risk factors for CAD but did not have angiographically significant CAD. MiR-126 was not significantly down-regulated or up-regulated in CAD patients and was not suitable for discriminating CAD patients from patients without CAD. The oppositely-directed relationship between miR-126 and LDL cholesterol in patients with or without CAD may have significant implications for identifying a potential role of miR-126 in cholesterol metabolism.
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DOI：
10.1016/j.bbrc.2010.12.119
发表时间：
2011-02-04
影响因子：
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作者：
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DOI：
10.1161/atvbaha.111.226696
发表时间：
2011-11-01
影响因子：
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