Atlas-Based Computational Analysis of Heart Shape and Function in Congenital Heart Disease.

Atlas-Based Computational Analysis of Heart Shape and Function in Congenital Heart Disease.
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DOI:
10.1007/s12265-017-9778-5
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发表时间:
2018-04
影响因子:
3.4
通讯作者:
McCulloch AD
McCulloch AD
中科院分区:
医学3区
文献类型:
--
作者:
Gilbert K;Forsch N;Hegde S;Mauger C;Omens JH;Perry JC;Pontré B;Suinesiaputra A;Young AA;McCulloch AD

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大约1%的婴儿出生时患有某种形式的先天性心脏缺陷。许多严重形式的CHD现在可以在出生后进行手术矫正,这导致了成年后生存率的提高。然而,许多患者需要连续监测来评估心力衰竭的进展并确定干预的时机。准确的多维量化的区域心脏的形状和功能,需要表征这些患者。单心室和双心室心脏形状和功能的计算图谱能够根据与特定参考人群相关的z分数量化重构。然后可以通过z分数的纵向评估来有效地监测疾病的进展。心脏功能的生物力学分析与人口变化的关系,使发展病理学的潜在机制的调查。在这里,我们总结了该领域的最新进展,并以单心室和双心室先天性病理为例。
Approximately 1% of all babies are born with some form of congenital heart defect. Many serious forms of CHD can now be surgically corrected after birth, which has lead to improved survival into adulthood. However, many patients require serial monitoring to evaluate progression of heart failure and determine timing of interventions. Accurate multidimensional quantification of regional heart shape and function are required for characterizing these patients. A computational atlas of single ventricle and biventricular heart shape and function enables quantification of remodeling in terms of z-scores in relation to specific reference populations. Progression of disease can then be monitored effectively by longitudinal evaluation of z-scores. A biomechanical analysis of cardiac function in relation to population variation enables investigation of the underlying mechanisms for developing pathology. Here, we summarize recent progress in this field, with examples in single ventricle and biventricular congenital pathologies.
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