High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover.
High prevalence of vitamin D insufficiency in China: relationship with the levels of parathyroid hormone and markers of bone turnover.
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DOI：
10.1371/journal.pone.0047264
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Zhang ZL
中科院分区：
文献类型：
--
作者：
Lu HK;Zhang Z;Ke YH;He JW;Fu WZ;Zhang CQ;Zhang ZL
目前缺乏对上海地区成年人维生素D状况及其与甲状旁腺激素（PTH）和骨转换标志物关系的大规模研究。目的是确定上海地区维生素D缺乏的患病率，并探讨25（OH）D与甲状旁腺功能和骨转换标志物的关系。本研究采用横断面研究方法，在上海市随机抽取20-89岁男性649人，女性1939人。测定血清25（OH）D、PTH、白蛋白和骨转换标志物的浓度。在冬季，男性维生素D不足（<30 ng/mL）的患病率为84%，女性为89%。维生素D缺乏症（<20 ng/mL）的患病率在男性中为30%，在女性中为46%。随着血清25（OH）D浓度的增加（分类为<10、10-20、20-30和≥30 ng/mL），两种性别的平均PTH和骨转换标志物水平逐渐降低（p<0.001）。在两种性别中，血清25（OH）D和PTH浓度之间呈反比关系，但没有观察到PTH水平达到平台的25（OH）D阈值。25（OH）D水平与骨转换标志物之间存在适度但显著的负相关关系，但血清25（OH）D水平高达40 ng/mL时未观察到平台期。
There is a lack of large-scale studies on vitamin D status and its relationship to parathyroid hormone (PTH) and bone turnover markers in adults living in Shanghai. The objectives were to determine the prevalence of vitamin D insufficiency in Shanghai and to investigate the relationship of 25(OH)D with parathyroid function and bone turnover markers. This cross-sectional study involved 649 men and 1939 women aged 20–89 years who were randomly sampled in Shanghai. Serum concentrations of 25(OH)D, PTH, albumin, and bone turnover markers were measured. During the winter season, the prevalence of vitamin D insufficiency (<30 ng/mL) was 84% in males and 89% in females. The prevalence of vitamin D deficiency (<20 ng/mL) was 30% in males and 46% in females. With increasing serum 25(OH)D concentrations categorized as <10, 10–20, 20–30, and ≥30 ng/mL, the mean PTH and bone turnover markers levels gradually decreasd in both sexes (p<0.001). There was an inverse relationship between the serum 25(OH)D and PTH concentrations in both genders, but no threshold of 25(OH)D at which PTH levels plateaued was observed. There were modest but significantly inverse relationships between the levels of 25(OH)D and bone turnover markers, but no plateau was observed for serum 25(OH)D levels up to 40 ng/mL.
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影响因子：
4
作者：
Ho-Pham, L. T.;Nguyen, N. D.;Nguyen, T. V.
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影响因子：
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