Regular insulin, rather than rapid-acting insulin, is a suitable choice for premeal bolus insulin in lean patients with type 2 diabetes mellitus.
Regular insulin, rather than rapid-acting insulin, is a suitable choice for premeal bolus insulin in lean patients with type 2 diabetes mellitus.
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DOI：
10.1111/j.2040-1124.2012.00231.x
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发表时间：
2013-01-29
影响因子：
3.2
通讯作者：
Matsuhisa M
中科院分区：
文献类型：
--
作者：
Kuroda A;Kaneto H;Kawashima S;Sakamoto K;Takahara M;Shiraiwa T;Yasuda T;Katakami N;Matsuoka TA;Shimomura I;Matsuhisa M
本研究的目的是比较餐前速效胰岛素和常规胰岛素在2型糖尿病患者中的有效性。对56例住院期间的2型糖尿病患者进行调查。使用餐前速效胰岛素代替其他药物。餐前胰岛素滴定调整餐前和睡前血糖水平为81 - 120mg /dL。如果餐后血糖水平低于餐前血糖水平，餐前速效胰岛素将在餐前改变为相同剂量的常规胰岛素。共有15名患者改为常规胰岛素，41名患者继续使用速效胰岛素。两组之间的血糖水平相当。使用常规胰岛素的患者体重指数明显较低。根据多变量logistic回归分析，低体重指数是考虑常规胰岛素有效性的独立变量。常规胰岛素，而不是速效胰岛素，是瘦型2型糖尿病患者餐前胰岛素的合适选择。
The aim of the present study was to compare the usefulness of premeal rapid‐acting and regular insulin in type 2 diabetes patients. A total of 56 type 2 diabetic patients were investigated during hospitalization. Premeal rapid‐acting insulin was applied instead of other medications. Premeal insulin was titrated to adjust premeal and bedtime blood glucose levels to 81–120 mg/dL. Premeal rapid‐acting insulin was changed to regular insulin just before a meal at the same dosage if the postmeal blood glucose level was lower than the premeal blood glucose level. A total of 15 patients changed to regular insulin, and 41 patients continued rapid‐acting insulin. The blood glucose level was comparable between these two groups. Body mass index was significantly lower in the patients using regular insulin. According to the multivariate logistic regression analysis, low body mass index was an independent variable accounting for the usefulness of regular insulin. Regular insulin, rather than rapid‐acting insulin, is a suitable choice for premeal insulin in lean type 2 diabetic patients.
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影响因子：
16.2
作者：
ROTHSCHILD, AH;WEINBERG, CR;PFEIFER, MA
通讯作者：
PFEIFER, MA
DOI：
10.1046/j.1440-1746.2000.02076.x
发表时间：
2000-04-01
影响因子：
4.1
作者：
Iida, M;Ikeda, M;Hori, M
通讯作者：
Hori, M
影响因子：
2.3
作者：
Salles, N.
通讯作者：
Salles, N.
影响因子：
16.2
作者：
VORA, JP;BURCH, A;OWENS, DR
通讯作者：
OWENS, DR
影响因子：
8.2
作者：
SINDELKA, G;HEINEMANN, L;CHANTELAU, E
通讯作者：
CHANTELAU, E