Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species.
Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species.
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DOI：
10.1155/2012/756132
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发表时间：
2012
影响因子：
--
通讯作者：
de Oliveira MR
中科院分区：
文献类型：
--
作者：
Gomes EC;Silva AN;de Oliveira MR
本文综述了运动过程中产生的反应性核素及其对运动适应的影响。活性物质和自由基是氧化其他分子以变得稳定的不稳定分子。虽然它们在我们的身体中发挥重要作用，但它们也会导致氧化应激，损害各种细胞功能。在运动过程中，活性物质主要但不完全通过以下机制产生：线粒体电子传递链的电子泄漏、缺血/再灌注和内皮黄嘌呤氧化酶的激活、炎症反应和儿茶酚胺的自氧化。慢性运动还导致身体抗氧化防御机制的上调，这有助于最大限度地减少急性运动后可能发生的氧化应激。最近的研究表明，在运动过程中产生的活性物质的有益作用，导致重要的训练适应：血管生成，线粒体生物合成和肌肉肥大。适应的发生取决于肌肉内的机械刺激，因此也是生物化学刺激。这是一个新的研究领域，有望在氧化应激和运动之间的关系所涉及的分子和细胞机制领域的重要发现。
This review offers an overview of the influence of reactive species produced during exercise and their effect on exercise adaptation. Reactive species and free radicals are unstable molecules that oxidize other molecules in order to become stable. Although they play important roles in our body, they can also lead to oxidative stress impairing diverse cellular functions. During exercise, reactive species can be produced mainly, but not exclusively, by the following mechanisms: electron leak at the mitochondrial electron transport chain, ischemia/reperfusion and activation of endothelial xanthine oxidase, inflammatory response, and autooxidation of catecholamines. Chronic exercise also leads to the upregulation of the body's antioxidant defence mechanism, which helps minimize the oxidative stress that may occur after an acute bout of exercise. Recent studies show a beneficial role of the reactive species, produced during a bout of exercise, that lead to important training adaptations: angiogenesis, mitochondria biogenesis, and muscle hypertrophy. The adaptations occur depending on the mechanic, and consequently biochemical, stimulus within the muscle. This is a new area of study that promises important findings in the sphere of molecular and cellular mechanisms involved in the relationship between oxidative stress and exercise.
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DOI：
10.1186/1476-5918-8-1
发表时间：
2009-01-13
期刊：
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影响因子：
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作者：
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