Neural Oscillatory Abnormalities During Gaze Processing in Schizophrenia: Evidence of Reduced Theta Phase Consistency and Inter-areal Theta-Gamma Coupling.
Neural Oscillatory Abnormalities During Gaze Processing in Schizophrenia: Evidence of Reduced Theta Phase Consistency and Inter-areal Theta-Gamma Coupling.
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精神分裂症期间凝视过程中的神经振荡异常：theta相一致性和抗抗硫代脉冲偶联的证据。
DOI：
10.1016/j.bpsc.2020.08.013
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Tso IF
中科院分区：
文献类型：
--
作者：
Grove TB;Lasagna CA;Martínez-Cancino R;Pamidighantam P;Deldin PJ;Tso IF
精神分裂症（SZ）的异常凝视辨别与社会功能障碍有关，但其神经机制尚不清楚。有证据表明，局部神经振荡和通过神经同步的区域间通信是支持基本和复杂认知过程的重要生理机制。这些机制在SZ异常注视处理中的作用尚未研究。本研究探讨了局部神经振荡和连接之间的前部和双侧后脑区在凝视处理。28 SZ和34名健康对照（HC）参与者完成了一个凝视辨别任务，在脑电图（EEG）记录。EEG数据的时频分解被用来检查双侧头皮后部和中线前部的神经振荡功率和试验间相位一致性。此外，使用Kullback-Leibler调制指数（KLMI）检查了这些前部和后部站点之间的连接性，即θ相位和伽马振幅之间的交叉频率耦合。在所有检查的地点，相对于HC，SZ显示出θ波段活动的总功率降低。这种组间差异可以解释为SZ试验间θ活动相位一致性的降低，这与SZ的凝视辨别准确性降低有关。此外，SZ表现出减少的KLMI指数的前馈和反馈之间的后部和前部网站的连接。这些研究结果表明，异常θ相位一致性和后面部处理和前区之间的连接障碍可能是SZ凝视处理缺陷的基础。
Abnormal gaze discrimination in schizophrenia (SZ) is associated with impairment in social functioning, but the neural mechanisms remain unclear. Evidence suggests that local neural oscillations and inter-areal communication through neural synchronization are critical physiological mechanisms supporting basic and complex cognitive processes. The roles of these mechanisms in abnormal gaze processing in SZ have not been investigated. The present study examined local neural oscillations and connectivity between anterior and bilateral posterior brain areas during gaze processing. Twenty-eight SZ and 34 healthy control (HC) participants completed a gaze discrimination task during electroencephalography (EEG) recording. Time-frequency decomposition of EEG data was used to examine neural oscillatory power and inter-trial phase consistency at bilateral posterior and midline anterior scalp sites. In addition, connectivity between these anterior and posterior sites, in terms of cross-frequency coupling between theta phase and gamma amplitude, was examined using the Kullback-Leibler Modulation Index (KLMI). SZ showed reduced total power of theta-band activity relative to HC at all sites examined. This group difference could be accounted for by SZ’s reduced inter-trial phase consistency of theta activity, which was related to reduced gaze discrimination accuracy in SZ. In addition, SZ exhibited reduced KLMI indexing both feedforward and feedback connectivity between the posterior and anterior sites. These findings suggest abnormal theta phase consistency and dysconnection between posterior face-processing and anterior areas may underlie gaze processing deficits in SZ.
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影响因子：
10.6
作者：
Butler PD;Silverstein SM;Dakin SC
通讯作者：
Dakin SC
影响因子：
10.6
作者：
Foss-Feig JH;Adkinson BD;Ji JL;Yang G;Srihari VH;McPartland JC;Krystal JH;Murray JD;Anticevic A
通讯作者：
Anticevic A
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
3.7
作者：
Gao, Chuanji;Conte, Stefania;Hanayik, Taylor
通讯作者：
Hanayik, Taylor
影响因子：
4.2
作者：
Adams, RB;Kleck, RE
通讯作者：
Kleck, RE