Keratin k15 as a biomarker of epidermal stem cells.
Keratin k15 as a biomarker of epidermal stem cells.
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DOI：
10.3390/ijms141019385
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发表时间：
2013-09-25
影响因子：
5.6
通讯作者：
Waseem A
中科院分区：
文献类型：
--
作者：
Bose A;Teh MT;Mackenzie IC;Waseem A
角蛋白15（K15）是与存在于所有复层上皮的基底角化细胞中的K5/K14对共表达的I型角蛋白。虽然它是细胞骨架的次要成分，具有可变的表达模式，但其表达已被报道为毛囊凸起中的干细胞标志物。相反，在正常和患病组织中也报道了K15的基底上表达，这与其作为干细胞标志物的作用不一致。我们最近发表的工作提供了似乎控制K15在未分化和分化细胞中表达的分子途径的证据。在本文中，我们批判性地回顾了已发表的工作，以确定K15作为表皮干细胞标志物的可靠性。
Keratin 15 (K15) is type I keratin protein co-expressed with the K5/K14 pair present in the basal keratinocytes of all stratified epithelia. Although it is a minor component of the cytoskeleton with a variable expression pattern, nonetheless its expression has been reported as a stem cell marker in the bulge of hair follicles. Conversely, suprabasal expression of K15 has also been reported in both normal and diseased tissues, which is inconsistent with its role as a stem cell marker. Our recently published work has given evidence of the molecular pathways that seem to control the expression of K15 in undifferentiated and differentiated cells. In this article, we have critically reviewed the published work to establish the reliability of K15 as an epidermal stem cell marker.
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影响因子：
3.3
作者：
Bloor, BK;Seddon, SV;Morgan, PR
通讯作者：
Morgan, PR
DOI：
10.1111/j.1365-2184.1986.tb00684.x
发表时间：
1986-05-01
期刊：
CELL AND TISSUE KINETICS
影响因子：
--
作者：
BICKENBACH, JR;MCCUTECHEON, J;MACKENZIE, IC
通讯作者：
MACKENZIE, IC
影响因子：
11.2
作者：
Biddle, Adrian;Liang, Xiao;Mackenzie, Ian C.
通讯作者：
Mackenzie, Ian C.
DOI：
10.1111/j.1468-3083.2010.03791.x
发表时间：
2011-03-01
影响因子：
9.2
作者：
Abbas, O.;Bhawan, J.
通讯作者：
Bhawan, J.
影响因子：
1.9
作者：
Kose, Osman;Lalli, Anand;Waseem, Ahmad
通讯作者：
Waseem, Ahmad