Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures.
Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures.
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岛叶细分和选择性疼痛相关大脑结构之间功能连接的性别差异。
DOI：
10.1186/s10194-018-0849-z
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发表时间：
2018-03-14
期刊：
影响因子：
--
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Dai YJ;Zhang X;Yang Y;Nan HY;Yu Y;Sun Q;Yan LF;Hu B;Zhang J;Qiu ZY;Gao Y;Cui GB;Chen BL;Wang W
背景女性疼痛障碍的发生率高于男性，这使得疼痛的性别差异成为研究焦点。人类岛叶皮层是疼痛处理的重要大脑中枢结构，并分为几个亚区，在疼痛感知中发挥不同的功能。在这里，我们的目的是研究的性别差异的功能连接（FC）之间的12个岛屿细分和选定的疼痛相关的大脑结构在healthadult.MethodsTwenty-six健康男性和11个年龄匹配的健康女性被招募在这个横断面研究。12个岛屿分区之间的功能界别（作为12个感兴趣区域（ROI））和整个大脑（ROI-全脑水平）或64个选定的疼痛相关脑区（64 ROI，ROI-ROI水平）之间的男性和女性进行了测量。ResultsSignificant gender differences in the FC of the insular subdivisions revealed：（1）两种方法均能使雄性大鼠背侧异常颗粒层（dId）与其他脑区之间的FC显著增加（ROI-全脑和ROI-ROI分析）;（2）基于ROI-全脑分析，在4个FC-对中观察到雄性的FC增加，包括左侧dId -右侧正中扣带回和副扣带回/右侧后扣带回/右侧楔前叶，左侧dId -右侧正中扣带回和副扣带回，左dId -左角回和左dId -左额中回;（3）根据ROI-ROI分析，男性左前扣带回dId与右前扣带回喙侧皮质之间的FC增加。本研究揭示了具有疼痛相关脑区的岛状分区的FC的性别差异，为疼痛处理的性别差异提供了神经影像学证据registrationClinicalTrials.gov。 NCT02820974 . 2016年6月28日注册。
BackgroundThe incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divided into several subdivisions, serving different functions in pain perception. Here we aimed to examine the gender differences of the functional connectivities (FCs) between the twelve insular subdivisions and selected pain-related brain structures in healthy adults.MethodsTwenty-six healthy males and 11 age-matched healthy females were recruited in this cross-sectional study. FCs between the 12 insular subdivisions (as 12 regions of interest (ROIs)) and the whole brain (ROI-whole brain level) or 64 selected pain-related brain regions (64 ROIs, ROI-ROI level) were measured between the males and females.ResultsSignificant gender differences in the FCs of the insular subdivisions were revealed: (1) The FCs between the dorsal dysgranular insula (dId) and other brain regions were significantly increased in males using two different techniques (ROI-whole brain and ROI-ROI analyses); (2) Based on the ROI-whole brain analysis, the FC increases in 4 FC-pairs were observed in males, including the left dId - the right median cingulate and paracingulate/ right posterior cingulate gyrus/ right precuneus, the left dId - the right median cingulate and paracingulate, the left dId - the left angular as well as the left dId - the left middle frontal gyrus; (3) According to the ROI-ROI analysis, increased FC between the left dId and the right rostral anterior cingulate cortex was investigated in males.ConclusionIn summary, the gender differences in the FCs of the insular subdivisions with pain-related brain regions were revealed in the current study, offering neuroimaging evidence for gender differences in pain processing.Trial registrationClinicalTrials.gov, NCT02820974 . Registered 28 June 2016.
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DOI：
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发表时间：
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期刊：
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