Immunological detection of hepatocellular carcinoma biomarker GP73 based on dissolved magnetic nanoparticles
Immunological detection of hepatocellular carcinoma biomarker GP73 based on dissolved magnetic nanoparticles
复制标题
基于溶解磁性纳米粒子的肝细胞癌生物标志物GP73的免疫学检测
DOI：
10.1016/j.colsurfa.2013.11.026
复制
发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Guo, Chen
中科院分区：
文献类型：
--
作者：
Xie, Li;Xia, Tingting;Xiong, Wubin;Guo, Chen
The peroxidase-like activity of dissolved Fe3O4magnetic nanoparticles was reported in this work. The chromogenic results of dissolved magnetic nanoparticles demonstrated almost the same change trend as standard ferric ion solutions. And the chromogenic reactions of dissolved Fe3O4magnetic nanoparticles were more sensitive than that of whole Fe3O4magnetic nanoparticles. The chromogenic reaction of dissolved Fe3O4magnetic nanoparticles was utilized to replace the chromogenic reaction of horseradish peroxidase in traditional enzyme-linked immunosorbent assay and applied in the immunoassay of hepatocellular carcinoma biomarker GP73. The method based on the chromogenic reaction of dissolved Fe3O4magnetic nanoparticles achieved a detection limit of 250 ng/mL, which was more sensitive than the method based on the peroxidase-like activity of whole Fe3O4magnetic nanoparticles. The immunological detection method based on dissolved Fe3O4magnetic nanoparticles proved to be simple, sensitive, specific and low-cost in this paper.
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