Lempel-Ziv complexity of cortical activity during sleep and waking in rats.
Lempel-Ziv complexity of cortical activity during sleep and waking in rats.
复制标题
DOI：
10.1152/jn.00575.2014
复制
发表时间：
2015-04-01
影响因子：
2.5
通讯作者：
Vyazovskiy VV
中科院分区：
文献类型：
--
作者：
Abásolo D;Simons S;Morgado da Silva R;Tononi G;Vyazovskiy VV
了解脑电、局部场电位(LFP)和神经元放电的动态变化对于解释其潜在的机制和生理意义是至关重要的。使用传统的脑电功率谱、相干性和周期-幅度分析已经了解了许多关于睡眠调节的知识，这些分析主要集中在信号的频率和幅度特征以及它们的时空同步性。然而，人们对正在进行的大脑状态或之前的睡眠-觉醒史对大脑活动的非线性动力学的影响知之甚少。在发展新的数学方法来研究大脑活动的时间结构方面的最新进展，如Lempel-Ziv复杂性(LZC)，可以提供超出传统信号分析技术的见解。在这里，我们使用大量的数据集，在自然清醒和睡眠的成年雄性实验大鼠中，以及在睡眠剥夺期间和之后，使用LZC方法对大脑皮质LFP和神经元的活动进行详细的分析。我们发现，与非快速眼动(NREM)睡眠相比，激活的大脑状态-清醒和快速眼动(REM)睡眠的特点是LZC更高。值得注意的是，从LFP得出的LZC值在睡眠剥夺后的NREM睡眠早期和个体NREM睡眠的中期特别低。我们的结论是，LZC是一种重要的但在很大程度上尚未被探索的指标，在研究健康和疾病中大脑活动的神经生理机制方面具有很高的潜力。
Understanding the dynamics of brain activity manifested in the EEG, local field potentials (LFP), and neuronal spiking is essential for explaining their underlying mechanisms and physiological significance. Much has been learned about sleep regulation using conventional EEG power spectrum, coherence, and period-amplitude analyses, which focus primarily on frequency and amplitude characteristics of the signals and on their spatio-temporal synchronicity. However, little is known about the effects of ongoing brain state or preceding sleep-wake history on the nonlinear dynamics of brain activity. Recent advances in developing novel mathematical approaches for investigating temporal structure of brain activity based on such measures, as Lempel-Ziv complexity (LZC) can provide insights that go beyond those obtained with conventional techniques of signal analysis. Here, we used extensive data sets obtained in spontaneously awake and sleeping adult male laboratory rats, as well as during and after sleep deprivation, to perform a detailed analysis of cortical LFP and neuronal activity with LZC approach. We found that activated brain states—waking and rapid eye movement (REM) sleep are characterized by higher LZC compared with non-rapid eye movement (NREM) sleep. Notably, LZC values derived from the LFP were especially low during early NREM sleep after sleep deprivation and toward the middle of individual NREM sleep episodes. We conclude that LZC is an important and yet largely unexplored measure with a high potential for investigating neurophysiological mechanisms of brain activity in health and disease.
登录
查看更多内容
睡眠唤起的三角洲频率反应显示，整个成人寿命的振幅线性下降。
影响因子：
4.2
作者：
Colrain, Ian M.;Crowley, Kate E.;Nicholas, Christian L.;Afifi, Lamia;Baker, Fiona C.;Padilla, Mayra;Turlington, Sharon R.;Trinder, John
通讯作者：
Trinder, John
影响因子：
4.8
作者：
Kralik, JD;Dimitrov, DF;Nicolelis, MAL
通讯作者：
Nicolelis, MAL
影响因子：
9.8
作者：
Cirelli C;Tononi G
通讯作者：
Tononi G
影响因子：
5.6
作者：
de Vivo, Luisa;Faraguna, Ugo;Cirelli, Chiara
通讯作者：
Cirelli, Chiara
影响因子：
5.6
作者：
Feinberg, I;Campbell, IG
通讯作者：
Campbell, IG