Dopamine signals related to appetitive and aversive events in paradigms that manipulate reward and avoidability.

Dopamine signals related to appetitive and aversive events in paradigms that manipulate reward and avoidability.
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DOI:
10.1016/j.brainres.2018.10.008
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发表时间:
2019-06-15
期刊:
影响因子:
2.9
通讯作者:
Roesch MR
Roesch MR
中科院分区:
医学3区
文献类型:
--
作者:
Gentry RN;Schuweiler DR;Roesch MR

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使用环境线索来获得好的东西和避免有害的东西对生存至关重要。奖励和厌恶的结果都通过强化学习来驱动行为,有时在环境中一起发生,但目前尚不清楚这些信号在大脑中是如何编码的,以及积极和消极强化的信号是否被类似地编码。最近的研究表明,多巴胺能系统和相互连接的脑区分别处理接近和回避行为所必需的积极和消极强化。在这里,我们回顾了这些数据,特别关注操纵预期回报和厌恶事件的可避免性的行为范式,以揭示与价值、预测误差编码、动机和显著度相关的神经关联。
Using environmental cues to acquire good and avoid harmful things is critical for survival. Rewarding and aversive outcomes both drive behavior through reinforcement learning and sometimes occur together in the environment, but it remains unclear how these signals are encoded within the brain and if signals for positive and negative reinforcement are encoded similarly. Recent studies demonstrate that the dopaminergic system and interconnected brain regions process both positive and negative reinforcement necessary for approach and avoidance behaviors, respectively. Here, we review these data with a special focus on behavioral paradigms that manipulate both expected reward and the avoidability of aversive events to reveal neural correlates related to value, prediction error encoding, motivation, and salience.
神经元型特异性信号,用于腹侧对段区域的奖励和惩罚。
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