Application of a biodegradable macromolecular contrast agent in dynamic contrast-enhanced MRI for assessing the efficacy of indocyanine green-enhanced photothermal cancer therapy.
Application of a biodegradable macromolecular contrast agent in dynamic contrast-enhanced MRI for assessing the efficacy of indocyanine green-enhanced photothermal cancer therapy.
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DOI：
10.1002/jmri.21838
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发表时间：
2009-08
影响因子：
4.4
通讯作者：
Lu, Zheng-Rong
中科院分区：
文献类型：
--
作者：
Feng, Yi;Emerson, Lyska;Jeong, Eun-Kee;Parker, Dennis L.;Lu, Zheng-Rong
关键词：
目的 研究基于聚二硫醚的可生物降解高分子造影剂 (Gd-DTPA)-胱胺共聚物 (GDCC) 在使用动态对比增强 MRI (DCE-MRI) 评估吲哚菁绿增强光热癌症治疗效果中的有效性。小鼠乳腺癌异种移植物被注射吲哚菁绿并用激光照射。使用 GDCC 为 40 KDa (GDCC-40) 的 DCE-MRI 在治疗后 4 小时和 7 天评估疗效。将肿瘤对 GDCC-40 的摄取拟合到二室模型以获得肿瘤血管参数，包括血浆分数 (fPV)、内皮转移系数 (KPS) 和通透性表面积乘积 (PS)。 GDCC-40 在三个剂量下产生相似的肿瘤血管参数，在较低剂量下产生较大的标准偏差。治疗后4小时，治疗后肿瘤的fPV、KPS和PS值比未治疗肿瘤小(p < 0.05)，治疗后7天恢复至治疗前值(p > 0.05)。 DCE-MRI 与 GDCC-40 可有效评估肿瘤对染料增强光热疗法的早期反应并检测治疗后的肿瘤复发。 GDCC-40 具有利用 DCE-MRI 无创监测抗癌治疗的潜力。
To investigate the effectiveness of a polydisulfide-based biodegradable macromolecular contrast agent, (Gd-DTPA)-cystamine copolymers (GDCC), in assessing the efficacy of indocyanine green enhanced photothermal cancer therapy using dynamic contrast enhanced MRI (DCE-MRI). Breast cancer xenografts in mice were injected with indocyanine green and irradiated with laser. The efficacy was assessed using DCE-MRI with GDCC of 40 KDa (GDCC-40) at 4 hours and 7 days after the treatment. The uptake of GDCC-40 by the tumors was fit to a two-compartment model to obtain tumor vascular parameters, including fractional plasma volume (fPV), endothelium transfer coefficient (KPS), and permeability surface area product (PS). GDCC-40 resulted in similar tumor vascular parameters at three doses with larger standard deviations at lower doses. The values of fPV, KPS and PS of the treated tumors were smaller (p < 0.05) than those of untreated tumors at 4 hours after the treatment and recovered to pretreatment values (p > 0.05) at 7 days after the treatment. DCE-MRI with GDCC-40 is effective for assessing tumor early response to dye-enhanced photothermal therapy and detecting tumor relapse after the treatment. GDCC-40 has a potential to non-invasively monitor anticancer therapies with DCE-MRI.
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影响因子：
8.8
作者：
Dodd, N J;Moore, J V;Poppitt, D G;Wood, B
通讯作者：
Wood, B
影响因子：
19.7
作者：
Prince, Martin R.;Zhang, Honglei;Valeri, Anthony M.
通讯作者：
Valeri, Anthony M.
影响因子：
9.6
作者：
HARRIES, SA;AMIN, Z;BOWN, SG
通讯作者：
BOWN, SG
影响因子：
6.7
作者：
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通讯作者：
van Dijke, CF
DOI：
10.1046/j.1524-4741.2003.09509.x
发表时间：
2003-09-01
期刊：
The breast journal
影响因子：
--
作者：
Korourian, Soheila;Klimberg, Suzanne;Harms, Steven
通讯作者：
Harms, Steven