Menthol preference moderates the relationship between cigarette nicotine content choice and reactions in young adults who smoke infrequently.
Menthol preference moderates the relationship between cigarette nicotine content choice and reactions in young adults who smoke infrequently.
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DOI：
10.1016/j.drugalcdep.2022.109580
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发表时间：
2022-09-01
影响因子：
4.2
通讯作者：
McClernon, F. Joseph
中科院分区：
文献类型：
--
作者：
Rubenstein, Dana;Sweitzer, Maggie M.;Scroggs, Lauren B.;Denlinger-Apte, Rachel L.;Kozink, Rachel;McClernon, F. Joseph
吸烟的年轻人中有一半使用薄荷醇香烟，这与持续吸烟和更大的尼古丁依赖有关。此外，对香烟的早期主观反应可以预测未来的使用。薄荷脑可能会减弱尼古丁的感觉效果。我们调查了薄荷醇对不常吸烟的年轻人对不同尼古丁含量香烟的主观反应和选择的调节作用。在三个平衡、双盲阶段中，吸烟≤ 15天/月的年轻成年人从极低（VLNC）、中等（INC）和正常（NNC）尼古丁含量香烟（根据偏好为薄荷醇或非薄荷醇）中吸烟固定剂量。参与者在最后一次会议上选择他们喜欢的香烟。积极和消极的主观反应，在每个会话进行了测量。ANOVA检验研究了薄荷醇偏好、尼古丁含量和主观反应之间的关系。参与者（N = 87）年龄为18-25岁，报告每月吸烟15.2支，超过8天（35%薄荷醇）。不喜欢薄荷醇的参与者对尼古丁含量更高的负面反应增加（F（1，55）= 10.76，p <0.001）;喜欢薄荷醇的参与者没有。对于非薄荷醇偏好的参与者，选择尼古丁含量较高的香烟与NNC和VLNC的阳性反应差异较大相关（F（1，55）= 12.72，p < .001），但对于薄荷醇偏好的参与者则不然。不经常吸烟的年轻人是烟草控制的重点人群，因为他们过渡到日常吸烟的风险很高。本研究以主观反应的形式得出的结果表明，尼古丁减少标准需要薄荷醇禁令才能在这一弱势群体中发挥最大作用。
Half of young adults who smoke use menthol cigarettes, which is associated with continued smoking and greater nicotine dependence. Additionally, early subjective reactions to cigarettes predict future use. Menthol may blunt the sensory effects of nicotine. We investigated the moderating role of menthol on subjective reactions to, and choice of varied nicotine content cigarettes in young adults who smoke infrequently. In three counterbalanced, double-blinded sessions, young adults who smoke ≤ 15 days/month smoked fixed doses from very low (VLNC), intermediate (INC), and normal (NNC) nicotine content cigarettes, which were menthol or non-menthol depending on preference. Participants chose their preferred cigarette in a final session. Positive and negative subjective reactions were measured in each session. ANOVA tests investigated the relationship between menthol preference, nicotine content, and subjective reactions. Participants (N = 87) were 18–25 years old and reported smoking 15.2 cigarettes per month over 8 days (35 % menthol). Non-menthol preferring participants had increased negative reactions with greater nicotine content (F(1, 55)= 10.76, p < .001); menthol preferring participants did not. Choice of higher nicotine cigarettes was associated with having reported a greater difference in positive reactions to NNC and VLNC for non-menthol preferring participants (F(1, 55)= 12.72, p < .001) but not for menthol preferring participants. Young adults who smoke infrequently are a priority tobacco control population given their high risk of transitioning to daily smoking. Results from this study in the form of subjective reactions indicate that a menthol ban is required for a nicotine reduction standard to be maximally effective in this vulnerable group.
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影响因子：
3.4
作者：
Sweitzer MM;Pacek LR;Kozink RV;Locey E;Kollins SH;Donny EC;McClernon FJ
通讯作者：
McClernon FJ
影响因子：
5.2
作者：
Klausner K
通讯作者：
Klausner K
影响因子：
4.7
作者：
Rios-Bedoya, Carlos F.;Pomerleau, Cynthia S.;Pomerleau, Ovide F.
通讯作者：
Pomerleau, Ovide F.
影响因子：
4.7
作者：
Cohn, Amy M.;Alexander, Adam C.;Ehlke, Sarah J.
通讯作者：
Ehlke, Sarah J.
影响因子：
6
作者：
Haberstick, Brett C.;Ehringer, Marissa A.;Hewitt, John K.
通讯作者：
Hewitt, John K.