Increased microstructural white matter correlations in left, but not right, temporal lobe epilepsy.
Increased microstructural white matter correlations in left, but not right, temporal lobe epilepsy.
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DOI：
10.1002/hbm.22614
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发表时间：
2015-01
影响因子：
4.8
通讯作者：
Tracy, Joseph
中科院分区：
文献类型：
--
作者：
Pustina, Dorian;Doucet, Gaelle;Sperling, Michael;Sharan, Ashwini;Tracy, Joseph
微结构白质束相关性已被证明反映了健康受试者系统发育和功能专业化的已知模式。本研究的目的是在一组对照中建立束间相关性，并检查颞叶癫痫 (TLE) 与正常状态的潜在偏差。我们研究了 28 名健康对照者的束间相关性，其中 21 名是左 TLE (LTLE)，23 名是右 TLE (RTLE)。研究了九个束，包括海马旁束、钩束、弓状束、额顶束和穹窿。 LTLE 中观察到束相关性异常增加，而 RTLE 显示束间相关性与对照组相似。在对照组中，束相关性随着各向异性分数 (FA) 的增加而增加，而在 TLE 组中，束相关性随着 FA 的减少而增加。聚类分析揭示了健康受试者中双侧同源束对的聚集，这些对在我们的 LTLE 和 RTLE 组中分开。判别分析旨在区分 LTLE 和 RTLE，表明束相关性比 FA 值产生更高的准确组分类率。我们的结果证实并扩展了之前的工作，表明与右侧 TLE 患者相比，左侧 TLE 患者不仅表现出更广泛的微观结构定向损失，而且还表现出更异常的束间相关性。异常相关性可能与病理过程（即癫痫发作扩散）或旨在保留关键认知功能的适应性过程有关。我们的数据表明束相关性可能在区分左右 TLE 方面具有预测价值，可能使扩散成像在临床实践中占据更重要的地位。
Microstructural white matter tract correlations have been shown to reflect known patterns of phylogenetic development and functional specialization in healthy subjects. The aim of this study was to establish inter-tract correlations in a group of controls, and examine potential deviations from normality in temporal lobe epilepsy (TLE). We investigated inter-tract correlations in 28 healthy controls, 21 left TLE (LTLE) and 23 right TLE (RTLE). Nine tracts were investigated, comprising the parahippocampal fasciculi, the uncinate fasciculi, the arcuate fasciculi, the frontoparietal tracts, and the fornix. An abnormal increase in tract correlations was observed in LTLE, while RTLE showed inter-tract correlations similar to controls. In the control group, tract correlations increased with increasing fractional anisotropy (FA), while in the TLE groups tract correlations increased with decreasing FA. Cluster analyses revealed agglomeration of bilateral pairs of homologous tracts in healthy subjects, with such pairs separated in our LTLE and RTLE groups. Discriminant analyses aimed at distinguishing LTLE from RTLE, revealing that tract correlations produce higher rates of accurate group classification than FA values. Our results confirm and extend previous work by showing that left compared to right TLE patients display, not only more extensive losses in microstructural orientation, but also more aberrant inter-tract correlations. Aberrant correlations may be related to pathologic processes (i.e., seizure spread) or to adaptive processes aimed at preserving key cognitive functions. Our data suggests tract correlations may have predictive value in distinguishing left from right TLE, potentially moving diffusion imaging to a place of greater prominence in clinical practice.
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影响因子：
5.6
作者：
Kemmotsu N;Girard HM;Bernhardt BC;Bonilha L;Lin JJ;Tecoma ES;Iragui VJ;Hagler DJ Jr;Halgren E;McDonald CR
通讯作者：
McDonald CR
影响因子：
4.8
作者：
Doucet, Gaelle;Osipowicz, Karol;Sharan, Ashwini;Sperling, Michael R.;Tracy, Joseph I.
通讯作者：
Tracy, Joseph I.
影响因子：
2.5
作者：
DEMETER, S;ROSENE, DL;VANHOESEN, GW
通讯作者：
VANHOESEN, GW
DOI：
10.3174/ajnr.a1650
发表时间：
2009-10
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Ahmadi ME;Hagler DJ Jr;McDonald CR;Tecoma ES;Iragui VJ;Dale AM;Halgren E
通讯作者：
Halgren E
影响因子：
2.5
作者：
Arfanakis, K;Hermann, B;Meyerand, ME
通讯作者：
Meyerand, ME