The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation.
The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation.
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DOI：
10.3389/fnins.2023.1150156
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发表时间：
2023
影响因子：
4.3
通讯作者：
Barron, Annelise E.
中科院分区：
文献类型：
--
作者：
Shamloo, Shirin;Defensor, Erwin;Ciari, Peter;Ogawa, Gaku;Vidano, Laura;Lin, Jennifer S.;Fortkort, John A.;Shamloo, Mehrdad;Barron, Annelise E.
关键词：
目前迫切需要一种能够预防或限制神经炎症过程和防止神经元变性的治疗方法。光生物调节（PBM），治疗使用特定波长的光，是一种安全的方法，具有抗炎作用。目前的研究旨在评估PBM对lps诱导的小鼠外周和中枢炎症的影响，以评估其作为抗炎治疗的潜力。在LPS攻击前10天，每天用红/近红外光（RL）或RL用40 Hz伽马频率闪烁治疗30分钟，显示出大脑和全身的抗炎作用。PBM下调LPS诱导与炎性小体活化相关的关键促炎细胞因子IL-1β和IL-18，上调抗炎细胞因子IL-10。RL具有强大的抗炎作用，而伽马闪烁的加入增强了这些作用。总的来说，这些结果表明，PBM作为一种抗炎治疗的潜力，通过细胞因子表达调节。
There is an urgent need for therapeutic approaches that can prevent or limit neuroinflammatory processes and prevent neuronal degeneration. Photobiomodulation (PBM), the therapeutic use of specific wavelengths of light, is a safe approach shown to have anti-inflammatory effects. The current study was aimed at evaluating the effects of PBM on LPS-induced peripheral and central inflammation in mice to assess its potential as an anti-inflammatory treatment. Daily, 30-min treatment of mice with red/NIR light (RL) or RL with a 40 Hz gamma frequency flicker for 10 days prior to LPS challenge showed anti-inflammatory effects in the brain and systemically. PBM downregulated LPS induction of key proinflammatory cytokines associated with inflammasome activation, IL-1β and IL-18, and upregulated the anti-inflammatory cytokine, IL-10. RL provided robust anti-inflammatory effects, and the addition of gamma flicker potentiated these effects. Overall, these results demonstrate the potential of PBM as an anti-inflammatory treatment that acts through cytokine expression modulation.
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影响因子：
4
作者：
Baik, Ji Soo;Lee, Tae Young;Shin, Yong-Il
通讯作者：
Shin, Yong-Il
低水平激光（光）治疗增加了C2C12肌管中的线粒体膜电位和ATP合成，在3-6 h时峰值响应。
影响因子：
3.3
作者：
Ferraresi C;Kaippert B;Avci P;Huang YY;de Sousa MV;Bagnato VS;Parizotto NA;Hamblin MR
通讯作者：
Hamblin MR
影响因子：
3.3
作者：
Hamblin MR
通讯作者：
Hamblin MR
DOI：
10.1089/photob.2018.4489
发表时间：
2019-02-01
影响因子：
1.8
作者：
Hipskind, S. Gregory;Grover, Fred L., Jr.;Hurtado, Timothy
通讯作者：
Hurtado, Timothy
影响因子：
5.3
作者：
Garza, Kristie M.;Zhang, Lu;Singer, Annabelle C.
通讯作者：
Singer, Annabelle C.