Identification of bullous pemphigoid, pemphigus, laminin, and anchoring fibril antigens in human fetal skin.

Identification of bullous pemphigoid, pemphigus, laminin, and anchoring fibril antigens in human fetal skin.
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人胎儿皮肤中大疱性类天疱疮、天疱疮、层粘连蛋白和锚定原纤维抗原的鉴定。

DOI:
10.1111/1523-1747.ep12274612
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发表时间:
1985
期刊:
The Journal of investigative dermatology
影响因子:
--
通讯作者:
Goldsmith,LA
Goldsmith,LA
中科院分区:
--
文献类型:
--
作者:
Lane,AT;Helm,KF;Goldsmith,LA

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人胎儿皮肤进行了评价的顺序和区域发展的几种表皮抗原。采用间接免疫荧光法检测层粘连蛋白、大疱性类天疱疮抗原、天疱疮抗原和锚定纤维抗原。83人胎儿皮肤活检32人胎儿进行了检查。检查的胎儿范围为估计胎龄(EGA)7-38周。层粘连蛋白存在于所有检查的胎儿组织的基底膜区。大疱性类天疱疮抗原在EGA 9周时首先出现在手掌和脚掌,到EGA 17周时出现在所有其他部位。11周EGA时存在天疱疮抗原。直到EGA 26周才出现AF 1和AF 2染色。AF 1和AF 2除了对基底膜区进行染色外,还对表皮基底细胞进行染色。比较人类胎儿皮肤发育与基底细胞癌,发现基底细胞癌与早期胎儿发育有相似之处。
Human fetal skin was evaluated for sequential and regional development of several epidermal antigens. Indirect immunofluorescent methods were used to detect laminin, bullous pemphigoid antigen, pemphigus antigen and anchoring fibril antigens identified by monoclonal antibodies AF1 and AF2. Eighty-three human fetal skin biopsies from 32 human fetuses were examined. The fetuses examined ranged from estimated gestational age (EGA) of 7–38 weeks. Laminin was present in the basement membrane zone of all the fetal tissues examined. Bullous pemphigoid antigen developed first in the palm and sole, 9 weeks EGA and was present in all other sites by 17 weeks EGA. Pemphigus antigen was present by 11 weeks EGA. AF1 and AF2 staining was not present until 26 weeks EGA. AF1 and AF2 stained epidermal basal cells in addition to the basement membrane zone area. Comparison of human fetal skin development with basal cell carcinoma identified similarities between basal cell carcinoma and early fetal development.
细胞培养物中表皮细胞形成基底层。
DOI: 10.1159/000396288
发表时间: 1981
期刊: Current problems in dermatology
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基底细胞上皮瘤中纤连蛋白和层粘连蛋白的分布。
DOI: 10.1111/1523-1747.ep12555545
发表时间: 1983
期刊: The Journal of investigative dermatology
影响因子: --
作者:
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