Identification of bullous pemphigoid, pemphigus, laminin, and anchoring fibril antigens in human fetal skin.
Identification of bullous pemphigoid, pemphigus, laminin, and anchoring fibril antigens in human fetal skin.
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人胎儿皮肤中大疱性类天疱疮、天疱疮、层粘连蛋白和锚定原纤维抗原的鉴定。
DOI:
10.1111/1523-1747.ep12274612
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发表时间:
1985
期刊:
影响因子:
--
通讯作者:
Goldsmith,LA
中科院分区:
文献类型:
--
作者:
Lane,AT;Helm,KF;Goldsmith,LA
Human fetal skin was evaluated for sequential and regional development of several epidermal antigens. Indirect immunofluorescent methods were used to detect laminin, bullous pemphigoid antigen, pemphigus antigen and anchoring fibril antigens identified by monoclonal antibodies AF1 and AF2. Eighty-three human fetal skin biopsies from 32 human fetuses were examined. The fetuses examined ranged from estimated gestational age (EGA) of 7–38 weeks. Laminin was present in the basement membrane zone of all the fetal tissues examined. Bullous pemphigoid antigen developed first in the palm and sole, 9 weeks EGA and was present in all other sites by 17 weeks EGA. Pemphigus antigen was present by 11 weeks EGA. AF1 and AF2 staining was not present until 26 weeks EGA. AF1 and AF2 stained epidermal basal cells in addition to the basement membrane zone area. Comparison of human fetal skin development with basal cell carcinoma identified similarities between basal cell carcinoma and early fetal development.
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DOI:
10.1159/000396288
发表时间:
1981
期刊:
Current problems in dermatology
影响因子:
--
作者:
T. Hirone;S. Taniguchi
通讯作者:
S. Taniguchi
影响因子:
3.6
作者:
K. Olson;G. Biberfeld;A. Fagraeus
通讯作者:
A. Fagraeus
影响因子:
3.6
作者:
A. Varelzidis;A. Tosca;E. Coumantakis;G. Nicolis;J. Hatzis;S. Papavasiliou;J. Stratigos
通讯作者:
J. Stratigos
影响因子:
6.5
作者:
HOLBROOK, KA;ODLAND, GF
通讯作者:
ODLAND, GF
DOI:
10.1111/1523-1747.ep12555545
发表时间:
1983
期刊:
The Journal of investigative dermatology
影响因子:
--
作者:
D. Nelson;C. Little;G. Balian
通讯作者:
G. Balian