Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility.
Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility.
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DOI：
10.1016/j.scitotenv.2016.10.038
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发表时间：
2017-01-15
影响因子：
9.8
通讯作者：
Liu, Danping
中科院分区：
文献类型：
--
作者：
Mendola, Pauline;Sundaram, Rajeshwari;Louis, Germaine M. Buck;Sun, Liping;Wallace, Maeve E.;Smarr, Melissa M.;Sherman, Seth;Zhu, Yeyi;Ying, Qi;Liu, Danping
我们的目标是在生育力和环境(LIFE)纵向调查研究(2005-2009)中研究靠近主要道路对尝试怀孕的夫妇的怀孕时间和不孕症的潜在影响，这是一项基于人群的前瞻性队列研究。尝试怀孕的夫妇(n=500)被登记并前瞻性跟踪，直到怀孕或尝试12个月，393对夫妇(78%)拥有完整的数据和完整的随访。怀孕时间是基于标准的方案，使用生育监测器，跟踪雌酮-3-葡萄糖苷和黄体生成素，以及怀孕测试试剂盒来检测人类绒毛膜促性腺激素(HCG)。用比例优势模型估计受精率优势比(FOR)和95%可信区间(CI)。不孕症定义为在没有hCG妊娠的情况下尝试怀孕12个月，用对数二项回归估计相对风险(RR)和95%可信区间(CI)。最终的模型根据年龄、产次、研究地点和唾液α-淀粉酶(一种压力标记)进行了调整。不育夫妇(53/393；14%)平均倾向于住在离主干道更近的地方(分别为689m比843m)，但差异无统计学意义。夫妇住所距离主干道每200米，怀孕的可能性就增加3%(FOR=1.03；CI=1.01-1.06)。与1000米或更远的距离相比，不孕不育症似乎也在中等距离内升高，但估计缺乏精确度。我们的发现表明，靠近主要道路可能与生殖力下降有关。来自更大人群的前瞻性数据是有根据的，可以证实这些发现。
We aimed to study the potential impact of proximity to major roadways on time-to-pregnancy and infertility in couples attempting pregnancy in the Longitudinal Investigation of Fertility and Environment (LIFE) study (2005-2009), a population-based, prospective cohort study. Couples attempting pregnancy (n=500) were enrolled and followed prospectively until pregnancy or 12 months of trying and 393 couples (78%) had complete data and full follow-up. Time-to-pregnancy was based on a standard protocol using fertility monitors, tracking estrone-3-glucuonide and luteinizing hormone, and pregnancy test kits to detect human chorionic gonadotropin (hCG). The fecundability odds ratio (FOR) and 95% confidence interval (CI) were estimated using proportional odds models. Infertility was defined as 12 months of trying to conceive without an hCG pregnancy and the relative risk (RR) and 95% CI were estimated with log-binomial regression. Final models were adjusted for age, parity, study site, and salivary alpha-amylase, a stress marker. Infertile couples (53/393; 14%) tended to live closer to major roadways on average than fertile couples (689 m vs. 843 m, respectively) but the difference was not statistically significant. The likelihood of pregnancy was increased 3% for every 200 meters further away the couples residence was from a major roadway (FOR=1.03; CI=1.01-1.06). Infertility also appeared elevated at moderate distances compared to 1000 meters or greater, but estimates lacked precision. Our findings suggest that proximity to major roadways may be related to reductions in fecundity. Prospective data from larger populations is warranted to corroborate these findings.
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