Effect of intermittent irradiation and fluence-response of 222 nm ultraviolet light on SARS-CoV-2 contamination.
Effect of intermittent irradiation and fluence-response of 222 nm ultraviolet light on SARS-CoV-2 contamination.
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222 nm紫外线间歇照射和剂量响应对SARS-CoV-2污染的影响
DOI：
10.1016/j.pdpdt.2021.102184
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发表时间：
2021-03
影响因子：
3.3
通讯作者：
Ohge H
中科院分区：
文献类型：
--
作者：
Kitagawa H;Nomura T;Nazmul T;Kawano R;Omori K;Shigemoto N;Sakaguchi T;Ohge H
报道了222 nm紫外光对严重急性呼吸综合征冠状病毒2型污染表面的消毒效果。本研究旨在评价222 nm中波紫外线间歇照射对SARS-CoV-2的影响以及222 nm中波紫外线对SARS-CoV-2灭活的剂量依赖性效应。分别用0.1mW/cm~2、0.05mW/cm~2、0.013 mW/cm~2和0.003 mW/cm~2的222nmUVC连续照射和间歇照射5min，比较连续照射和间歇照射对SARS-CoV-2灭活效果的影响。对于间歇照射，我们遵循开关照射周期，每10次S照射一次，然后380次S照射。此后，我们评估了0.1mW/cm2、0.013 mW/cm2和0.003 mW/cm2 222 nm紫外线照射对SARS-CoV-2污染的影响，每种照射下的紫外线通量分别为1、2和3mJ/cm2。在每次照射下，连续照射和间歇照射对SARS-CoV-2的对数减少率无显著差异。在每个紫外线照射剂量下，三种不同辐照水平对SARS-CoV-2病毒的对数减少率没有显著差异。222nmUVC连续照射与间歇照射对SARS-CoV-2的灭活无显著差异。此外，222 nm UVC以剂量依赖的方式灭活SARS-CoV-2。222纳米紫外线照射在减少SARS-CoV-2污染方面的效果需要在现实世界中进一步评估。
The effectiveness of 222 nm ultraviolet (UV) C light for disinfecting surfaces contaminated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The aim of this study was to evaluate the effect of the intermittent irradiation of 222 nm UVC on SARS-CoV-2 and the fluence-dependent effect of 222 nm UVC irradiation on SARS-CoV-2 inactivation. We experimented with 5 min continuous and intermittent irradiation for 0.1, 0.05, 0.013, and 0.003 mW/cm2 of 222 nm UVC to evaluate the differences in the effect of the continuous and intermittent irradiation of 222 nm UVC on SARS-CoV-2 inactivation. For intermittent irradiation, we followed the on-off irradiation cycles with every 10-s irradiation followed by a 380-s interval. Thereafter, we evaluated the effects of 0.1, 0.013, and 0.003 mW/cm2 222 nm UVC irradiation on SARS-CoV-2 contamination at UV fluences of 1, 2, and 3 mJ/cm2 at each irradiance. At each irradiance, no significant difference was observed in the log reduction of SARS-CoV-2 between continuous and intermittent irradiation. At each UV fluence, no significant difference was observed in the log reduction of SARS-CoV-2 among the three different irradiance levels. There was no significant difference between continuous and intermittent irradiation with 222 nm UVC with regards to SARS-CoV-2 inactivation. Moreover, 222 nm UVC inactivates SARS-CoV-2 in a fluence-dependent manner. The efficacy of 222-nm UVC irradiation in reducing the contamination of SARS-CoV-2 needs to be further evaluated in a real-world setting.
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