Immune Response to Enterococcus gallinarum in Lupus Patients Is Associated With a Subset of Lupus-Associated Autoantibodies.
Immune Response to Enterococcus gallinarum in Lupus Patients Is Associated With a Subset of Lupus-Associated Autoantibodies.
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DOI：
10.3389/fimmu.2021.635072
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发表时间：
2021
影响因子：
7.3
通讯作者：
Deshmukh US
中科院分区：
文献类型：
--
作者：
Bagavant H;Araszkiewicz AM;Ingram JK;Cizio K;Merrill JT;Arriens C;Guthridge JM;James JA;Deshmukh US
肠道微生物和免疫系统之间的相互作用会影响自身免疫性疾病，如系统性红斑狼疮（SLE）。最近，一种革兰氏阳性的肠道细菌，鸡肠球菌被认为是SLE的候选致病菌。本研究旨在评价E.鸡暴露对SLE临床参数的影响。由于循环中抗全菌IgG抗体已被确定为细菌暴露的替代标志物，因此抗E。在来自俄克拉荷马州风湿病队列的SLE患者和健康对照的库存血清样品中测量鸡IgG抗体。抗E.研究了鸡群抗体滴度和狼疮的临床指标。在一组患者中研究了人RNA抗体。结果表明，病人和健康人血清中均存在与E.鸡。两组之间的抗体滴度无差异。而伴有核糖体P自身抗体的SLE患者抗E抗体水平较高。与健康对照相比，鸡IgG滴度。除了抗核糖体P，更高的抗E。抗dsDNA和抗Sm自身抗体的存在也显着相关的鸡球虫滴度。在有抗核糖体P和抗dsDNA的患者亚组中，抗E。鸡的抗体滴度与抗人RNA抗体显著相关。我们的数据表明，健康人和SLE患者对E。鸡。SLE患者对E.鸡伤寒沙门氏菌与对狼疮自身抗原的特定亚群的抗体应答相关。这些发现为E.鸡球虫可能是SLE易感个体的致病菌。
Interactions between gut microbes and the immune system influence autoimmune disorders like systemic lupus erythematosus (SLE). Recently, Enterococcus gallinarum, a gram-positive commensal gut bacterium, was implicated as a candidate pathobiont in SLE. The present study was undertaken to evaluate the influence of E. gallinarum exposure on clinical parameters of SLE. Since circulating IgG antibodies to whole bacteria have been established as a surrogate marker for bacterial exposure, anti-E. gallinarum IgG antibodies were measured in banked serum samples from SLE patients and healthy controls in the Oklahoma Cohort for Rheumatic Diseases. The associations between anti-E. gallinarum antibody titers and clinical indicators of lupus were studied. Antibodies to human RNA were studied in a subset of patients. Our results show that sera from both patients and healthy controls had IgG and IgA antibodies reactive with E. gallinarum. The antibody titers between the two groups were not different. However, SLE patients with Ribosomal P autoantibodies had higher anti-E. gallinarum IgG titers compared to healthy controls. In addition to anti-Ribosomal P, higher anti-E. gallinarum titers were also significantly associated with the presence of anti-dsDNA and anti-Sm autoantibodies. In the subset of patients with anti-Ribosomal P and anti-dsDNA, the anti-E. gallinarum titers correlated significantly with antibodies to human RNA. Our data show that both healthy individuals and SLE patients were sero-reactive to E. gallinarum. In SLE patients, the immune response to E. gallinarum was associated with antibody response to a specific subset of lupus autoantigens. These findings provide additional evidence that E. gallinarum may be a pathobiont for SLE in susceptible individuals.
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影响因子：
3.3
作者：
Mostafa, Gehan A.;Ibrahim, Dalia H.;Mohammed, Azza K.
通讯作者：
Mohammed, Azza K.
影响因子：
15.9
作者：
KOREN, E;REICHLIN, MW;REICHLIN, M
通讯作者：
REICHLIN, M
影响因子：
6.7
作者：
Calich, Ana L.;Viana, Vilma S. T.;Bonfa, Eloisa
通讯作者：
Bonfa, Eloisa
影响因子：
6.7
作者：
Ebersole, JL;Cappelli, D;ODell, DS
通讯作者：
ODell, DS
影响因子：
--
作者：
Press, J;Palayew, K;Silverman, ED
通讯作者：
Silverman, ED