Unilateral thalamic glioma disrupts large-scale functional architecture of human brain during resting state
Unilateral thalamic glioma disrupts large-scale functional architecture of human brain during resting state
复制标题
单侧丘脑胶质瘤在静息状态下破坏人脑的大规模功能结构
DOI：
10.2147/ndt.s186161
复制
发表时间：
2019-04
影响因子：
3.2
通讯作者：
Xu Haibo
中科院分区：
文献类型：
--
作者：
Li Sirui;Gao Lei;Liu Ying;Ao Yawen;Xu Haibo
背景丘脑是大脑深部重要结构，负责大脑节律的同步和皮质活动的整合。人脑成像和计算建模已非侵入性地揭示了其在维持皮质网络架构和功能层次结构中的作用。目的本研究的目的是确定单侧丘脑损伤对人脑内在功能结构的影响。患者和方法 我们在 3.0 T 磁共振扫描仪上收集了所有参与者的 8 分钟静息态功能磁共振成像 (R-fMRI) 数据：一名术前左丘脑因间变性星形细胞瘤（WHO III 级星形细胞瘤）破坏的患者和 20 名匹配的健康对照。分析 R-fMRI 数据的功能连接性和自发波动的幅度。结果患者表现出初级感觉网络和高级认知网络内的功能连接显着下降，以及网络间耦合的广泛改变。对自发活动幅度的进一步分析表明，特别是在默认模式网络和 Papez 电路的拓扑结构中，自发活动的幅度显着下降。结论这一结果为丘脑损伤对自发性大脑活动的相关性和景观的影响提供了证据，促进了我们对丘脑损伤对大规模大脑网络影响的理解。
Background The thalamus is an important deep brain structure for the synchronization of brain rhythm and the integration of cortical activity. Human brain imaging and computational modeling have non-invasively revealed its role in maintaining the cortical network architecture and functional hierarchy. Purpose The objective of this study was to identify the effect of unilateral thalamic damage on the human brain intrinsic functional architecture. Patients and methods We collected an 8-minute resting-state functional magnetic resonance imaging (R-fMRI) data on a 3.0 T magnetic resonance scanner for all the participants: a preoperative patient with left thalamus destroyed by anaplastic astrocytoma (WHO grade III type of astrocytoma) and 20 matched healthy controls. The R-fMRI data was analyzed for functional connectivity and amplitude of spontaneous fluctuations. Results The patient showed prominent decrease in functional connectivity within primary sensory networks and advanced cognitive networks, and extensive alterations in between-network coupling. Further analysis of the amplitude of spontaneous activity suggested significant decrease especially in the topographies of default mode network and the Papez circuit. Conclusion This result provided evidence about the consequences of thalamic destruction on the correlation and landscape of spontaneous brain activity, promoting our understanding of the effects of thalamic damage on large-scale brain networks.
登录
查看更多内容
影响因子：
3.7
作者：
Shao Y;Wang L;Ye E;Jin X;Ni W;Yang Y;Wen B;Hu D;Yang Z
通讯作者：
Yang Z
慢性原发性失眠局部固有振荡的频率依赖性变化：静息状态下低频波动幅度的研究
DOI：
10.1016/j.nicl.2016.05.011
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Zhou F;Huang S;Zhuang Y;Gao L;Gong H
通讯作者：
Gong H
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
Tao Blockindeng
通讯作者：
Tao Blockindeng
DOI：
10.1176/appi.ajp.2012.12010056
发表时间：
2012-10
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Woodward ND;Karbasforoushan H;Heckers S
通讯作者：
Heckers S
影响因子：
2.5
作者：
Xiaodan Yan;Adam D. Brown;M. Lazar;V. Cressman;Clare Henn-Haase;T. Neylan;A. Shalev;O. Wolkowitz;S. Hamilton;R. Yehuda;D. Sodickson;M. Weiner;C. Marmar
通讯作者：
Xiaodan Yan;Adam D. Brown;M. Lazar;V. Cressman;Clare Henn-Haase;T. Neylan;A. Shalev;O. Wolkowitz;S. Hamilton;R. Yehuda;D. Sodickson;M. Weiner;C. Marmar