Decreased thalamocortical functional connectivity after 36 hours of total sleep deprivation: evidence from resting state FMRI.
Decreased thalamocortical functional connectivity after 36 hours of total sleep deprivation: evidence from resting state FMRI.
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DOI：
10.1371/journal.pone.0078830
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Shao Y;Wang L;Ye E;Jin X;Ni W;Yang Y;Wen B;Hu D;Yang Z
丘脑和大脑皮层通过地形学组织的相互连接连接，这在分离内部和外部定向的意识信息方面具有关键功能。先前的任务相关研究已经揭示了完全睡眠剥夺（TSD）后丘脑活动的改变。然而，目前还不清楚TSD如何影响丘脑和大脑皮层之间的通信。本研究采用静息态功能磁共振成像（fMRI）技术，观察了完全睡眠剥夺36小时后丘脑皮质功能连接的变化。招募了14名健康志愿者，并在TSD 36小时前后进行了fMRI扫描。采用基于种子的功能连接分析，并测试了休息觉醒（RW）和TSD条件下丘脑皮质功能连接的差异。我们发现，与正常睡眠相比，TSD后右侧丘脑与右侧海马旁回、右侧颞中回和右侧额上级回在静息状态下的功能连接减少。左侧丘脑与右侧额内侧回、双侧颞中回和左侧额上级回的连接减少。这些结果表明TSD后丘脑皮质功能连接发生了破坏性变化，可能导致唤醒水平和信息整合能力下降，进而影响人类的认知功能。
The thalamus and cerebral cortex are connected via topographically organized, reciprocal connections, which hold a key function in segregating internally and externally directed awareness information. Previous task-related studies have revealed altered activities of the thalamus after total sleep deprivation (TSD). However, it is still unclear how TSD impacts on the communication between the thalamus and cerebral cortex. In this study, we examined changes of thalamocortical functional connectivity after 36 hours of total sleep deprivation by using resting state function MRI (fMRI). Fourteen healthy volunteers were recruited and performed fMRI scans before and after 36 hours of TSD. Seed-based functional connectivity analysis was employed and differences of thalamocortical functional connectivity were tested between the rested wakefulness (RW) and TSD conditions. We found that the right thalamus showed decreased functional connectivity with the right parahippocampal gyrus, right middle temporal gyrus and right superior frontal gyrus in the resting brain after TSD when compared with that after normal sleep. As to the left thalamus, decreased connectivity was found with the right medial frontal gyrus, bilateral middle temporal gyri and left superior frontal gyrus. These findings suggest disruptive changes of the thalamocortical functional connectivity after TSD, which may lead to the decline of the arousal level and information integration, and subsequently, influence the human cognitive functions.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
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发表时间：
2009-06-23
影响因子：
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作者：
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