Factors associated with the success of rabies vaccination of dogs in Sweden.
Factors associated with the success of rabies vaccination of dogs in Sweden.
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DOI：
10.1186/1751-0147-53-22
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发表时间：
2011-03-25
影响因子：
2.1
通讯作者：
Klingeborn B
中科院分区：
文献类型：
--
作者：
Berndtsson LT;Nyman AK;Rivera E;Klingeborn B
联合王国、爱尔兰、马耳他和瑞典在关于狂犬病疫苗接种和狂犬病中和抗体个人血清学检测规则的过渡期内维持其国家规定。为犬只注射狂犬病疫苗的目的是建立暴露前免疫力，并保护个别动物免受狂犬病感染。该研究的目的是调查犬接种狂犬病疫苗后达到国际公认的阈值抗体滴度0.5 IU/mL的相关因素。该研究是一项前瞻性单队列研究，包括来自瑞典接种市售疫苗的6，789只瑞典犬的样本，通过OIE批准的FAVN试验确定犬的抗体应答。收集每只犬的潜在风险因素信息;品种、年龄、性别、接种日期、疫苗标签和接种次数。使用logistic回归分析研究了因变量血清学应答≥ 0.5 IU/mL或< 0.5 IU/mL与每个潜在风险因素之间的相关性。在6，789只接种犬中，6，241只（91.9%）的获批检测结果≥ 0.5 IU/mL。多变量logistic回归分析结果显示，与接种疫苗A相比，接种疫苗B可将抗体滴度< 0.5 IU/mL的风险降低0.2倍。发现品种大小与疫苗接种次数的相互作用和疫苗接种时的年龄与末次疫苗接种后抗体检测日的相互作用具有显著性。总之，较大的品种具有抗体滴度< 0.5 IU/mL的较高风险，但如果接种两次，则该风险降低。此外，< 6 months of age and >5岁犬的抗体滴度< 0.5 IU/mL的风险增加，但这受到从接种疫苗到检测的天数的影响。犬只接种狂犬病疫苗的成功概率取决于所用疫苗的类型、接种狂犬病疫苗的次数、犬只的品种大小、接种时的年龄以及接种后检测抗体滴度的天数。对于较大品种的狗，建议需要加强接种方案。
United Kingdom, Ireland, Malta and Sweden maintain their national provisions for a transitional period regarding rules concerning rabies vaccination and individual serological test for rabies neutralizing antibodies. The purpose of vaccinating dogs against rabies is to establish pre-exposure immunity and protect individual animals from contracting rabies. The aim of the study was to investigate factors associated with reaching the internationally accepted threshold antibody titre of 0.5 IU/mL after rabies vaccination of dogs. The study was a prospective single cohort study including 6,789 samples from Swedish dogs vaccinated with commercially available vaccines in Sweden, and the dog's antibody responses were determined by the OIE approved FAVN test. Information on potential risk factors; breed, age, gender, date of vaccination, vaccine label and the number of vaccinations, was collected for each dog. Associations between the dependent variable, serological response ≥ 0.5 IU/mL or < 0.5 IU/mL and each of the potential risk factors were investigated using logistic regression analysis. Of 6,789 vaccinated dogs, 6,241 (91.9%) had an approved test result of ≥ 0.5 IU/mL. The results of the multivariable logistic regression analysis showed that vaccinating with vaccine B reduced the risk of having antibody titres of < 0.5 IU/mL by 0.2 times compared with vaccination using vaccine A. Breed size was found significant as an interaction with number of vaccinations and age at vaccination as an interaction with day of antibody testing after last vaccination. In summary, larger breeds were at higher risk of having antibody titres of < 0.5 IU/mL but if vaccinated twice this risk was reduced. Moreover, there were a increased risk for dogs < 6 months of age and > 5 years of age to have antibody titres of < 0.5 IU/mL, but this was affected by number of days from vaccination till testing. The probability of success of rabies vaccinations of dogs depends on type of vaccine used, number of rabies vaccinations, the breed size of the dog, age at vaccination, and number of days after vaccination when the antibody titres are tested. The need for a booster vaccination regimen is recommended for larger breeds of dog.
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影响因子：
5.5
作者：
Kennedy, Lorna J.;Lunt, Mark;Ollier, William E. R.
通讯作者：
Ollier, William E. R.
影响因子：
1.7
作者：
Moore, SM;Ricke, TA;Briggs, DJ
通讯作者：
Briggs, DJ
影响因子：
0.8
作者：
HogenEsch, H.;Thompson, S.
通讯作者：
Thompson, S.
影响因子：
3.3
作者：
Minke, J. M.;Bouvet, J.;Guigal, P. M.
通讯作者：
Guigal, P. M.
影响因子：
0.8
作者：
Day, M. J.
通讯作者：
Day, M. J.