Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae
Outer surface protein polymorphisms linked to host‐spirochete association in Lyme borreliae
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外表面蛋白多态性与莱姆疏螺旋体宿主螺旋体关联相关
DOI：
10.1111/mmi.14209
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发表时间：
2019
影响因子：
3.6
通讯作者：
Lin, Yi‐Pin
中科院分区：
文献类型：
--
作者：
Tufts, Danielle M.;Hart, Thomas M.;Chen, Grace F.;Kolokotronis, Sergios‐Orestis;Diuk‐Wasser, Maria A.;Lin, Yi‐Pin
莱姆疏螺旋体病是由多种螺旋体细菌Borrelia burgdorferisensu lato引起的。螺旋体通过蜱传播给脊椎动物宿主，包括小型和中型哺乳动物，鸟类，爬行动物和人类。已记录了宿主特异性感染性的菌株间差异，但驱动这种差异的分子基础仍不清楚。螺旋体具有逃避宿主免疫应答和定殖宿主组织以在脊椎动物宿主中建立感染的能力。反过来，宿主在被不同种/株的莱姆病疏螺旋体入侵时产生不同水平的免疫应答。类似地，莱姆病疏螺旋体定殖宿主组织的能力在不同的螺旋体物种/菌株之间变化。驱动免疫逃避和定殖的这种菌株间差异的一种潜在机制是莱姆病螺旋体产生的多态性外表面蛋白。在这篇综述中，我们总结了菌株间宿主能力变异的研究，并讨论了支持螺旋体产生的蛋白质多态性在驱动宿主特异性变异中的作用的证据。这些信息将提供更深入的了解驱动主机和莱姆病螺旋体协会的适应机制，这将导致干预措施的发展，以阻止病原体的传播，并最终减少莱姆病螺旋体的健康负担。
Lyme borreliosis is caused by multiple species of the spirochete bacteriaBorrelia burgdorferisensu lato. The spirochetes are transmitted by ticks to vertebrate hosts, including small‐ and medium‐sized mammals, birds, reptiles, and humans. Strain‐to‐strain variation in host‐specific infectivity has been documented, but the molecular basis that drives this differentiation is still unclear. Spirochetes possess the ability to evade host immune responses and colonize host tissues to establish infection in vertebrate hosts. In turn, hosts have developed distinct levels of immune responses when invaded by different species/strains of Lyme borreliae. Similarly, the ability of Lyme borreliae to colonize host tissues varies among different spirochete species/strains. One potential mechanism that drives this strain‐to‐strain variation of immune evasion and colonization is the polymorphic outer surface proteins produced by Lyme borreliae. In this review, we summarize research on strain‐to‐strain variation in host competence and discuss the evidence that supports the role of spirochete‐produced protein polymorphisms in driving this variation in host specialization. Such information will provide greater insights into the adaptive mechanisms driving host and Lyme borreliae association, which will lead to the development of interventions to block pathogen spread and eventually reduce Lyme borreliosis health burden.
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影响因子：
1.2
作者：
R. Picken;M. Picken
通讯作者：
M. Picken
北美本土鸟类对莱姆病螺旋体、伯氏疏螺旋体的储存能力
影响因子：
2.1
作者：
H. Ginsberg;P. Buckley;Maxon G. Balmforth;E. Zhioua;S. Mitra;F. G. Buckley
通讯作者：
F. G. Buckley
DOI：
10.1086/592279
发表时间：
2008-11-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Wormser GP;Brisson D;Liveris D;Hanincová K;Sandigursky S;Nowakowski J;Nadelman RB;Ludin S;Schwartz I
通讯作者：
Schwartz I
影响因子：
3.1
作者：
Hovis, KM;Tran, E;Marconi, RT
通讯作者：
Marconi, RT
影响因子：
4.4
作者：
Hanincová, K;Taragelová, V;Kurtenbach, K
通讯作者：
Kurtenbach, K