Effect of HAART on salivary gland function in the Women's Interagency HIV Study (WIHS).
Effect of HAART on salivary gland function in the Women's Interagency HIV Study (WIHS).
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DOI：
10.1111/j.1601-0825.2008.01456.x
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发表时间：
2009-01
期刊：
影响因子：
3.8
通讯作者：
Oral Substudy of the Women's Interagency HIV Study Collaborative Study Group*
中科院分区：
文献类型：
--
作者：
Navazesh M;Mulligan R;Karim R;Mack WJ;Ram S;Seirawan H;Greenspan J;Greenspan D;Phelan J;Alves M;Oral Substudy of the Women's Interagency HIV Study Collaborative Study Group*
确定高效抗逆转录病毒治疗（HAART）对来自妇女机构间HIV研究（WIHS）的HIV阳性妇女唾液腺功能的影响。纵向队列研究。WIHS队列中共有668名HIV阳性女性接受了初始和至少1次随访口服子研究访视，共接受了5358次访视。根据口干问卷、整体未刺激和刺激唾液流速、唾液腺肿大或触诊大唾液腺时压痛和唾液缺乏评估唾液腺功能。任何给定访视时未刺激和刺激流速相对于前一次访视的变化（连续变量）。自我报告的口干（存在/不存在）、唾液腺增大或触痛（存在/不存在）以及唾液腺触诊无分泌物的发生为二元结局（是/否）。与非基于PI的HAART相比，基于蛋白酶抑制剂（PI）的HAART是发生未刺激（p=0.01）和刺激（p=0.0004）唾液流速降低以及唾液腺增大（p=0.006）的显著风险因素。基于PI的HAART治疗是HIV阳性患者唾液流速降低和唾液腺增大的重要风险因素。
To determine the impact of highly active antiretroviral therapy (HAART) on salivary gland function in HIV positive women from the Women's Interagency HIV Study (WIHS). Longitudinal cohort study. A total of 668 HIV positive women from the WIHS cohort with an initial and at least 1 follow-up oral sub-study visit contributed 5358 visits. Salivary gland function was assessed based on a dry mouth questionnaire, whole unstimulated and stimulated salivary flow rates, salivary gland enlargement or tenderness and lack of saliva on palpation of the major salivary glands. Changes in unstimulated and stimulated flow rates at any given visit from that of the immediate prior visit (continuous variables). The development of self-reported dry mouth (present/absent), enlargement or tenderness of salivary glands (present/absent), and absence of secretion on palpation of the salivary glands were binary outcomes (yes/no). Protease Inhibitor (PI) based HAART was a significant risk factor for developing decreased unstimulated (p=0.01) and stimulated (p=0.0004) salivary flow rates as well as salivary gland enlargement (p=0.006) as compared with non-PI based HAART. PI-based HAART therapy is a significant risk factor for developing reduced salivary flow rates and salivary gland enlargement in HIV positive patients.
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影响因子：
4.9
作者：
Kozinetz, CA;Carter, AB;Kline, MW
通讯作者：
Kline, MW
影响因子：
--
作者：
Kravcik, S
通讯作者：
Kravcik, S
DOI：
10.1016/j.tripleo.2005.07.021
发表时间：
2006-09-01
影响因子：
--
作者：
Lin, Alan L.;Johnson, Dorthea A.;Yeh, Chih-Ko
通讯作者：
Yeh, Chih-Ko
影响因子：
5.4
作者：
Barkan, SE;Melnick, SL;Feldman, J
通讯作者：
Feldman, J
DOI：
10.1111/j.0301-5661.2004.00128.x
发表时间：
2004-04-01
影响因子：
2.3
作者：
Mulligan, R;Phelan, JA;Alves, MEAF
通讯作者：
Alves, MEAF