Striatal GABA-MRS predicts response inhibition performance and its cortical electrophysiological correlates.
Striatal GABA-MRS predicts response inhibition performance and its cortical electrophysiological correlates.
复制标题
DOI：
10.1007/s00429-014-0873-y
复制
发表时间：
2015-11
影响因子：
3.1
通讯作者：
Beste C
中科院分区：
文献类型：
--
作者：
Quetscher C;Yildiz A;Dharmadhikari S;Glaubitz B;Schmidt-Wilcke T;Dydak U;Beste C
反应抑制过程对行为监测很重要，通过不同皮质区域和基底节核团组成的网络进行调节。在基底节水平，已知纹状体GABA能中棘神经元对反应选择很重要，但纹状体GABA能系统对反应抑制过程的重要性仍不清楚。利用行为、脑电和磁共振波谱(MRS)数据的新组合，我们检查了纹状体GABA能系统与反应抑制过程的相关性。研究表明，纹状体GABA水平调节反应抑制过程的效果。纹状体GABA水平越高，反应抑制效果越好。我们发现纹状体GABA通过调节神经元同步过程来调节与运动前抑制过程相关的反应抑制的特定子过程。据我们所知，这是第一个为人类纹状体GABA能系统与反应抑制功能及其皮层电生理相关性提供直接证据的研究。
Response inhibition processes are important for performance monitoring and are mediated via a network constituted by different cortical areas and basal ganglia nuclei. At the basal ganglia level, striatal GABAergic medium spiny neurons are known to be important for response selection, but the importance of the striatal GABAergic system for response inhibition processes remains elusive. Using a novel combination of behavioural, EEG and magnetic resonance spectroscopy (MRS) data we examine the relevance of the striatal GABAergic system for response inhibition processes. The study shows that striatal GABA levels modulate the efficacy of response inhibition processes. Higher striatal GABA levels were related to better response inhibition performance. We show that striatal GABA modulate specific subprocesses of response inhibition related to pre-motor inhibitory processes through the modulation of neuronal synchronization processes. To our knowledge this is the first study providing direct evidence for the relevance of the striatal GABAergic system for response inhibition functions and their cortical electrophysiological correlates in humans.
登录
查看更多内容
影响因子：
5.7
作者：
Boehler, C. N.;Appelbaum, L. G.;Krebs, R. M.;Hopf, J. M.;Woldorff, M. G.
通讯作者：
Woldorff, M. G.
影响因子：
2.6
作者：
Beste, Christian;Saft, Carsten
通讯作者：
Saft, Carsten
影响因子：
3.2
作者：
Hester, RL;Murphy, K;Garavan, H
通讯作者：
Garavan, H
影响因子：
2.9
作者：
Boer, Vincent O.;Siero, Jeroen C. W.;Klomp, Dennis W. J.
通讯作者：
Klomp, Dennis W. J.
影响因子：
4.4
作者：
Chowdhury, Fahmida A.;O'Gorman, Ruth L.;Richardson, Mark P.
通讯作者：
Richardson, Mark P.