Tough and strong porous bioactive glass-PLA composites for structural bone repair.
Tough and strong porous bioactive glass-PLA composites for structural bone repair.
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DOI：
10.1007/s10853-017-0777-3
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发表时间：
2017-08
影响因子：
4.5
通讯作者：
Rahaman MN
中科院分区：
文献类型：
--
作者：
Xiao W;Zaeem MA;Li G;Bal BS;Rahaman MN
生物活性玻璃支架已被用于治愈小的骨缺损，但由于对其机械可靠性的担忧，它们在修复结构骨方面的应用受到限制。在本研究中，研究了在强多孔生物活性玻璃（13-93）支架的外表面添加粘附聚合物层以提高其韧性。由多孔玻璃和粘附聚合物层组成的梁的弯曲机械响应的有限元建模 (FEM) 预测，随着聚合物层厚度和弹性模量的增加，玻璃中的拉伸应力会减小。由 13-93 玻璃和聚乳酸 (PLA) 形成的结构与模型相似的复合材料的机械测试显示了 FEM 模拟预测的趋势，但观察到的效果要显着得多。厚度为-400μm的PLA层，等于支架厚度的-12.5%，使支架在四点弯曲时的承载能力增加了约50%。断裂功增加超过 10,000%，产生非脆性机械响应。这些生物活性玻璃-PLA复合材料结合了生物活性、高强度、高断裂功以及有利于骨浸润的内部结构，可以为治疗结构性骨缺损提供最佳的植入物。
Bioactive glass scaffolds have been used to heal small contained bone defects but their application to repairing structural bone is limited by concerns about their mechanical reliability. In the present study, the addition of an adherent polymer layer to the external surface of strong porous bioactive glass (13–93) scaffolds was investigated to improve their toughness. Finite element modeling (FEM) of the flexural mechanical response of beams composed of a porous glass and an adherent polymer layer predicted a reduction in the tensile stress in the glass with increasing thickness and elastic modulus of the polymer layer. Mechanical testing of composites with structures similar to the models, formed from 13–93 glass and polylactic acid (PLA), showed trends predicted by the FEM simulations but the observed effects were considerably more dramatic. A PLA layer of thickness −400 µm, equal to −12.5% of the scaffold thickness, increased the load-bearing capacity of the scaffold in four-point bending by ~50%. The work of fracture increased by more than 10,000%, resulting in a non-brittle mechanical response. These bioactive glass–PLA composites, combining bioactivity, high strength, high work of fracture and an internal architecture shown to be conducive to bone infiltration, could provide optimal implants for healing structural bone defects.
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DOI：
10.3390/ma7054001
发表时间：
2014-05-21
期刊：
Materials (Basel, Switzerland)
影响因子：
--
作者：
Martínez-Vázquez FJ;Pajares A;Guiberteau F;Miranda P
通讯作者：
Miranda P
影响因子：
9.7
作者：
Rahaman, Mohamed N.;Day, Delbert E.;Bal, B. Sonny;Fu, Qiang;Jung, Steven B.;Bonewald, Lynda F.;Tomsia, Antoni P.
通讯作者：
Tomsia, Antoni P.
影响因子：
4.9
作者：
Martinez-Vazquez, Francisco J.;Perera, Fidel H.;Miranda, Pedro
通讯作者：
Miranda, Pedro
DOI：
10.1016/j.jeurceramsoc.2012.05.005
发表时间：
2012-11-01
影响因子：
5.7
作者：
Deliormanli, Aylin M.;Rahaman, Mohamed N.
通讯作者：
Rahaman, Mohamed N.
用于大骨修复的生物活性玻璃
影响因子：
10
作者：
Jia, Weitao;Lau, Grace Y.;Fu, Qiang
通讯作者：
Fu, Qiang