The COVID-19 outbreak in Italy: Initial implications for organ transplantation programs.
The COVID-19 outbreak in Italy: Initial implications for organ transplantation programs.
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DOI：
10.1111/ajt.15904
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发表时间：
2020-07
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--
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2019冠状病毒病（COVID-19）的传播已于数周内达到大流行程度。意大利是最早应对COVID-19疫情的国家之一，已采取严厉措施限制病毒传播。COVID-19的传播可能会对器官移植活动产生一些影响，医生应该意识到这一点。在COVID-19爆发期间获得的初步经验显示，意大利约10%的受感染患者需要重症监护管理以克服急性呼吸窘迫综合征。由于感染患者的指数上升，我们现在面临着重症监护病房（ICU）床位饱和的实际风险。对供者和移植受者使用的ICU床位数量的限制可能会对整体捐赠活动产生不利影响，并最终导致移植数量减少。意大利的初步数据显示，在COVID-19爆发的前4周，采购器官已经减少了25%。这突显出有必要密切监测由于COVID-19传播而在ICU中进一步发生的情况，以试图保护移植活动，特别是在西方国家，死者捐赠者代表主要器官资源。
The spread of Coronavirus Disease 2019 (COVID-19) has already reached a pandemic dimension within a few weeks. Italy has been one of the first countries dealing with the outbreak of COVID-19, and severe measures have been adopted to limit viral transmission. The spread of COVID-19 may have several implications in organ transplant activity that physicians should be aware of. The initial experience gained during the COVID-19 outbreak shows that around 10% of infected patients in Italy need intensive care management to overcome the acute respiratory distress syndrome. Due to the exponential rise of infected patients we are now facing an actual risk of saturation of intensive care unit (ICU) beds. A restriction in the number of ICU beds available for both donors and transplant recipients may unfavorably influence the overall donation activity, and eventually lead to a reduced number of transplants. Preliminary Italian data show that a 25% reduction of procured organs has already occurred during the first 4 weeks of COVID-19 outbreak. This underlines the need to closely monitor what will be further happening in ICUs due to the COVID-19 spread in the attempt to preserve transplant activity, especially in Western countries where deceased donors represent the major organ resource.
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