Structure-function relationships of postnatal tendon development: a parallel to healing.

Structure-function relationships of postnatal tendon development: a parallel to healing.
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DOI:
10.1016/j.matbio.2013.01.007
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发表时间:
2013-03-11
期刊:
影响因子:
6.9
通讯作者:
Soslowsky, Louis J.
Soslowsky, Louis J.
中科院分区:
生物学1区
文献类型:
--
作者:
Connizzo, Brianne K.;Yannascoli, Sarah M.;Soslowsky, Louis J.

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本文综述了肌腱结构与功能关系的最新研究,并对肌腱发育与愈合之间的相似性进行了评论。肌腱发育和胶原纤维形成的过程进行了审查,但由于在这一领域的信息丰富,这项工作主要集中在表征成熟和发育肌腱的力学行为,以及后者如何平行愈合肌腱。细胞外基质成分,主要是胶原蛋白,蛋白多糖和胶原交联,在确定肌腱的力学行为中发挥的作用将在这篇综述中进行研究。具体地,胶原纤维重新排列和胶原纤维解卷曲将机械行为与发育期间和愈合期间的结构改变相关联。最后,我们关注了最近为增强受伤肌腱而做出的一些努力,以及未来的努力如何集中精力重建这里所回顾的重要结构-功能关系。
This review highlights recent research on structure-function relationships in tendon and comments on the parallels between development and healing. The processes of tendon development and collagen fibrillogenesis are reviewed, but due to the abundance of information in this field, this work focuses primarily on characterizing the mechanical behavior of mature and developing tendon, and how the latter parallels healing tendon. The role that extracellular matrix components, mainly collagen, proteoglycans, and collagen cross-links, play in determining the mechanical behavior of tendon will be examined in this review. Specifically, collagen fiber re-alignment and collagen fibril uncrimping relate mechanical behavior to structural alterations during development and during healing. Finally, attention is paid to a number of recent efforts to augment injured tendon and how future efforts could focus on recreating the important structure-function relationships reviewed here.
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