Host Genetic Control of the Oral Microbiome in Health and Disease.
Host Genetic Control of the Oral Microbiome in Health and Disease.
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DOI：
10.1016/j.chom.2017.08.013
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发表时间：
2017-09-13
影响因子：
30.3
通讯作者：
Nelson KE
中科院分区：
文献类型：
--
作者：
Gomez A;Espinoza JL;Harkins DM;Leong P;Saffery R;Bockmann M;Torralba M;Kuelbs C;Kodukula R;Inman J;Hughes T;Craig JM;Highlander SK;Jones MB;Dupont CL;Nelson KE
与宿主相关的微生物群落受到宿主遗传学和环境因素的影响。然而，控制人类口腔微生物组的因素及其对疾病的影响仍有待研究。为了确定宿主基因型和环境对口腔微生物组组成和龋齿表型的综合和相对影响，我们对 485 名 5 至 11 岁双卵和同卵双胞胎的龈上菌斑微生物组进行了分析。无论龋齿状态如何，口腔微生物组的相似性总是随着宿主基因型的共享而增加。此外，尽管口腔微生物组的大部分变异是由环境因素决定的，但仍鉴定出了高度遗传的口腔分类群。最有遗传性的口腔细菌与龋齿状态无关，不倾向于与其他分类群同时出现，并且数量随着年龄和糖摄入频率而减少。因此，虽然人类口腔微生物组的组成受到宿主遗传背景的影响，但潜在的致龋类群可能不受遗传因素控制。戈麦斯等人。检查 5 至 11 岁双胞胎的龈上菌斑微生物组，发现早期口腔微生物组是由遗传和环境因素共同塑造的。然而，最具遗传性的细菌数量会随着年龄的增长而减少，并且潜在的致龋类群不受宿主遗传学的控制。
Host-associated microbial communities are influenced by both host genetics and environmental factors. However, factors controlling the human oral microbiome and their impact on disease remain to be investigated. To determine the combined and relative effects of host genotype and environment on oral microbiome composition and caries phenotypes, we profiled the supragingival plaque microbiome of 485 dizygotic and monozygotic twins aged five to eleven. Oral microbiome similarity always increased with shared host genotype, regardless of caries state. Additionally, although most of the variation in the oral microbiome was determined by environmental factors, highly heritable oral taxa were identified. The most heritable oral bacteria were not associated with caries state, did not tend to co-occur with other taxa, and decreased in abundance with age and sugar consumption frequency. Thus, while the human oral microbiome composition is influenced by host genetic background, potentially cariogenic taxa are likely not controlled by genetic factors. Gomez et al. examine the supragingival plaque microbiome of five to eleven year old twins and find that the early oral microbiome is shaped by both heritable and environmental factors. However, the most heritable bacteria diminish in abundance with age and potentially cariogenic taxa are not controlled by host genetics.
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影响因子：
3
作者：
Corby, PMA;Bretz, WA;Vanyukov, M
通讯作者：
Vanyukov, M
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
14.6
作者：
Azad, Meghan B.;Konya, Theodore;Kozyrskyj, Anita L.
通讯作者：
Kozyrskyj, Anita L.
DOI：
10.1073/pnas.1000080107
发表时间：
2011-03-15
影响因子：
11.1
作者：
Caporaso, J. Gregory;Lauber, Christian L.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
48
作者：
Edgar, Robert C.
通讯作者：
Edgar, Robert C.