Influence of Early Life, Diet, and the Environment on the Microbiome.
Influence of Early Life, Diet, and the Environment on the Microbiome.
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DOI：
10.1016/j.cgh.2018.08.067
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Gupta A
中科院分区：
文献类型：
--
作者：
Dong TS;Gupta A
测序技术和生物信息学的进步极大地提高了我们了解人类微生物组的能力。在过去的十年里，越来越多的文献将营养和环境与微生物群联系起来，现在认为微生物群是整体健康的重要因素。本文回顾了过去10年的文献，重点介绍了环境因素如饮食、早期生活逆境和压力在塑造和改变我们的微生物群对健康和疾病的影响。这项研究表明，分娩方式、母乳、压力、饮食和药物等许多因素都会极大地影响我们肠道微生物群的发育，并可能使我们更容易患上某些疾病。通过将环境因素纳入研究健康和疾病环境下微生物组的模型，可以更好地了解疾病和潜在的新治疗领域。为了强调这一点，我们将进一步探索环境和微生物组在肥胖和功能性肠道疾病发展中的作用。
Advances in sequencing technology and bioinformatics have greatly enhanced our ability to understand the human microbiome. Over the last decade, a growing body of literature has linked nutrition and the environment to the microbiome and is now thought to be an important contributor to overall health. This paper reviews the literature from the past 10 years to highlight the influence of environmental factors such as diet, early life adversity and stress in shaping and modifying our microbiome towards health and disease. The review shows that many factors such as the mode of delivery, breast milk, stress, diet and medications can greatly influence the development of our gut microbiome and potentially make us more prone to certain diseases. By incorporating environmental factors into models that study the microbiome in the setting of health and disease, may provide a better understanding of disease and potentially new areas of treatment. To highlight this, we will additionally explore the role of the environment and the microbiome in the development of obesity and functional bowel disorders.
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1186/1710-1492-9-15
发表时间：
2013
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
Azad MB;Konya T;Maughan H;Guttman DS;Field CJ;Sears MR;Becker AB;Scott JA;Kozyrskyj AL
通讯作者：
Kozyrskyj AL
影响因子：
15.5
作者：
de Muinck EJ;Trosvik P;Gilfillan GD;Hov JR;Sundaram AYM
通讯作者：
Sundaram AYM
影响因子：
4.9
作者：
Biedermann, Luc;Bruelisauer, Karin;Schuppler, Markus
通讯作者：
Schuppler, Markus
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob