Central infusion of interleukin-1 receptor antagonist blocks the reduction in social behavior produced by prior stressor exposure.
Central infusion of interleukin-1 receptor antagonist blocks the reduction in social behavior produced by prior stressor exposure.
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DOI：
10.1016/j.physbeh.2009.04.024
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发表时间：
2009-08-04
影响因子：
2.9
通讯作者：
Deak, Terrence
中科院分区：
文献类型：
--
作者：
Arakawa, Hiroyuki;Blandino, Peter, Jr.;Deak, Terrence
ARAKAWA，H.，P. Blandino Jr.和T Deak。中枢输注白细胞介素1受体拮抗剂可阻断先前应激源暴露引起的社会行为减少。《物理学》SDE V **（*）000-000，2009年。促炎细胞因子如脑中的白细胞介素-1 β（IL-1β）调节啮齿类动物的疾病行为，其中动物表现出复杂的行为变化，如一般活动减少、社会动机降低和发热反应。本研究采用两种不同的行为模式，研究了脂多糖（LPS）和应激源（足电击）暴露对Sprague-Dawley大鼠后期社会行为表达的影响。在实验1中，在LPS或足部电击处理后的4个不同时间点进行了传统的社会互动测试，其中允许动物在其家中笼中研究幼年大鼠。在实验2中，社会调查任务，允许动物嗅连接到其他腔室，其中放置刺激动物，但防止身体接触的孔，被用来测量LPS或足电击治疗后的几个时间点的社会调查。全身注射LPS（100 μg/kg）和2小时足电击暴露（80次电击，1 mA，5秒持续时间）均引起社会互动的时间依赖性减少（实验1）。1)调查（Exp。2）、LPS处理的大鼠显示出更深刻的减少社会调查从2小时至6小时后处理，而大鼠暴露于footshock暴露后6小时显示减少。在实验3中，通过预先注射IL-1受体拮抗剂（IL-1 Ra; 100 μg icv）来阻断足电击引起的社会调查减少。总之，这些发现支持了越来越多的文献表明，压力依赖性变化的脑细胞因子在介导的行为后果的压力暴露发挥了关键作用。
ARAKAWA, H., P. BLANDINO Jr. AND T DEAK. Central infusion of interleukin-1 receptor antagonist blocks the reduction in social behavior produced by prior stressor exposure. PHYSIOL BEHAV **(*) 000-000, 2009.-Pro-inflammatory cytokines such as interleukin-1beta (IL-1β) in the brain modulate sickness behavior in rodents, in which animals show complex changes in behavior such as reduction of general activity, reduced social motivation, and fever response. The present studies examined the impact of lipopolysacharide (LPS) and stressor (footshock) exposure on the later expression of social behavior in Sprague-Dawley rats using two separate behavioral paradigms. In Experiment 1, a traditional test for social interaction in which animals were allowed to investigate a juvenile rat in their home cages was conducted at 4 different time points following LPS or foot shock treatment. In Experiment 2, social investigation task which allowed animals to sniff the hole connected to other chamber where a stimulus animal was placed, but prevented physical contact, was used to measure social investigation at several time points following LPS or footshock treatment. Both systemic infusion of LPS (100 μg/kg) and 2 hr footshock exposure (80 shocks, 1mA, 5 sec duration) elicited a time-dependent reduction of social interaction (Exp. 1) and investigation (Exp. 2); LPS-treated rats displayed a more profound reduction of social investigation from 2 hr to 6 hr after treatment, while rats exposed to footshock showed a reduction 6 hr after the footshock exposure. In Experiment 3, the footshock-induced reduction of social investigation was blocked by pretreatment with IL-1 receptor antagonist (IL-1Ra; 100 μg icv) infusion. Together, these findings support a growing body of literature showing that stress-dependent changes in brain cytokines play a key role in mediating behavioral consequences of stressor exposure.
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影响因子：
2.7
作者：
Arakawa, Hiroyuki;Arakawa, Keiko;Blanchard, Robert J.
通讯作者：
Blanchard, Robert J.
影响因子：
2.7
作者：
Deak, T;Bellamy, C;Bordner, KA
通讯作者：
Bordner, KA
影响因子：
3.4
作者：
Fishkin, RJ;Winslow, JT
通讯作者：
Winslow, JT
DOI：
10.1111/j.1749-6632.1988.tb21627.x
发表时间：
1988-12-30
影响因子：
5.2
作者：
DINARELLO, CA
通讯作者：
DINARELLO, CA
影响因子：
2.7
作者：
File, SE
通讯作者：
File, SE