Lead exposure, B vitamins, and plasma homocysteine in men 55 years of age and older: the VA normative aging study.
Lead exposure, B vitamins, and plasma homocysteine in men 55 years of age and older: the VA normative aging study.
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DOI：
10.1289/ehp.1306931
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发表时间：
2014-10
影响因子：
10.4
通讯作者：
Weuve J
中科院分区：
文献类型：
--
作者：
Bakulski KM;Park SK;Weisskopf MG;Tucker KL;Sparrow D;Spiro A 3rd;Vokonas PS;Nie LH;Hu H;Weuve J
背景：铅 (Pb) 暴露可能会影响同型半胱氨酸的血浆浓度，同型半胱氨酸是一种与心血管和神经退行性疾病相关的单碳代谢物。人们对铅和同型半胱氨酸之间随时间的关系或饮食因素的潜在影响知之甚少。目的：我们研究了近期和累积铅暴露与同型半胱氨酸浓度的纵向关联以及参与一碳代谢的膳食营养素的潜在改变作用。方法：在退伍军人事务部 (VA) 规范衰老研究的一个子队列中（1,056 名男性，1993 年至 2011 年间总共进行了 2,301 次观察），我们使用混合效应模型来估计重复测量的总血浆同型半胱氨酸随血液和胫骨中 Pb 浓度的差异，分别评估近期和累积的 Pb 暴露。我们还评估了饮食摄入量和叶酸、维生素 B6 和维生素 B12 血浆浓度的影响。结果：血铅 (3 μg/dL) 的四分位距 (IQR) 增量与同型半胱氨酸浓度升高 6.3% 相关（95% CI：4.8，7.8%）。胫骨 Pb 的 IQR 增量 (14 μg/g) 与同型半胱氨酸升高 3.7% (95% CI: 1.6, 5.6%) 相关，在调整血 Pb 后，同型半胱氨酸升高至 1.5% (95% CI: –0.5, 3.6%)。相比之下，与基线相比时间增加 5 年与同型半胱氨酸增加 5.7% 相关（95% CI：4.3，7.1%）。在估计膳食维生素 B6 和叶酸摄入量低于（与高于）研究人群中位数的参与者中，血铅和同型半胱氨酸之间的关联性明显更强，这与美国推荐的膳食津贴摄入量相似。结论：铅暴露与血浆同型半胱氨酸浓度呈正相关。这种关联在维生素 B6 和叶酸膳食摄入量低于中位数的男性中更为明显。这些发现表明，增加叶酸和维生素 B6 的摄入量可能会减少与铅相关的同型半胱氨酸的增加，同型半胱氨酸是心血管疾病和神经退行性疾病的危险因素。引用：Bakulski KM、Park SK、Weisskopf MG、Tucker KL、Sparrow D、Spiro A III、Vokonas PS、Nie LH、Hu H、Weuve J. 2014。55 岁及以上男性的铅暴露、B 族维生素和血浆同型半胱氨酸：VA 规范性衰老研究。环境健康视角 122：1066–1074； http://dx.doi.org/10.1289/ehp.1306931
Background: Lead (Pb) exposure may influence the plasma concentration of homocysteine, a one-carbon metabolite associated with cardiovascular and neurodegenerative diseases. Little is known about the associations between Pb and homocysteine over time, or the potential influence of dietary factors. Objectives: We examined the longitudinal association of recent and cumulative Pb exposure with homocysteine concentrations and the potential modifying effect of dietary nutrients involved in one-carbon metabolism. Methods: In a subcohort of the Veterans Affairs (VA) Normative Aging Study (1,056 men with 2,301 total observations between 1993 and 2011), we used mixed-effects models to estimate differences in repeated measures of total plasma homocysteine across concentrations of Pb in blood and tibia bone, assessing recent and cumulative Pb exposure, respectively. We also assessed effect modification by dietary intake and plasma concentrations of folate, vitamin B6, and vitamin B12. Results: An interquartile range (IQR) increment in blood Pb (3 μg/dL) was associated with a 6.3% higher homocysteine concentration (95% CI: 4.8, 7.8%). An IQR increment in tibia bone Pb (14 μg/g) was associated with a 3.7% higher homocysteine (95% CI: 1.6, 5.6%), which was attenuated to 1.5% (95% CI: –0.5, 3.6%) after adjusting for blood Pb. For comparison, a 5-year increase in time from baseline was associated with a 5.7% increase in homocysteine (95% CI: 4.3, 7.1%). The association between blood Pb and homocysteine was significantly stronger among participants with estimated dietary intakes of vitamin B6 and folate below (vs. above) the study population medians, which were similar to the U.S. recommended dietary allowance intakes. Conclusions: Pb exposure was positively associated with plasma homocysteine concentration. This association was stronger among men with below-median dietary intakes of vitamins B6 and folate. These findings suggest that increasing intake of folate and B6 might reduce Pb-associated increases in homocysteine, a risk factor for cardiovascular disease and neurodegeneration. Citation: Bakulski KM, Park SK, Weisskopf MG, Tucker KL, Sparrow D, Spiro A III, Vokonas PS, Nie LH, Hu H, Weuve J. 2014. Lead exposure, B vitamins, and plasma homocysteine in men 55 years of age and older: the VA Normative Aging Study. Environ Health Perspect 122:1066–1074; http://dx.doi.org/10.1289/ehp.1306931
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