Helicobacter species in cancers of the gallbladder and extrahepatic biliary tract.
Helicobacter species in cancers of the gallbladder and extrahepatic biliary tract.
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DOI：
10.1038/sj.bjc.6604780
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发表时间：
2009-01-13
影响因子：
8.8
通讯作者：
Franceschi, S.
中科院分区：
文献类型：
--
作者：
de Martel, C.;Plummer, M.;Parsonnet, J.;van Doorn, L-J;Franceschi, S.
在人类胆汁和胆道（BT）组织中发现了螺杆菌，并怀疑其引起BT疾病，包括胆囊癌和肝外癌，在本研究中统称为BT癌症。我们对胆汁或BT活检中存在螺杆菌与BT癌症和良性疾病相关的流行病学证据进行了文献综述。报告显示，在研究方法方面存在很大差异。确定了9项关于BT癌症的研究，所有研究均为30种或更少的BT癌症; 8项包括无癌症对照受试者，并使用聚合酶链反应（PCR）作为螺杆菌物种检测的手段。在其中4项研究中，至少在使用无BT疾病的对照时，在BT癌症患者中检测到的螺杆菌种类显著高于对照组。在两项研究中，在病例组和对照组中均未检测到螺杆菌。在良性BT疾病如胆石病或慢性胆囊炎中也经常检测到螺杆菌。由于我们目前的知识依赖于一些显示出实质性差异的小型研究，因此需要更大规模的研究和更标准化的方案来检测针对螺杆菌物种的DNA和抗体，以调查与BT癌症的潜在关联。
Helicobacter species have been found in human bile and biliary tract (BT) tissue and are suspected to cause BT diseases, including gallbladder and extrahepatic cancers, collectively referred to in this work as BT cancers. We conducted a literature review of the epidemiological evidence linking the presence of Helicobacter species in bile or BT biopsies to BT cancers and benign diseases. Reports showed great variability with respect to study methods. Nine studies of BT cancers were identified, all with 30 or fewer BT cancers; eight included cancer-free control subjects and used polymerase chain reaction (PCR) as a means of Helicobacter species detection. In four of these studies, Helicobacter species were detected in patients with BT cancer significantly more frequently than in controls, at least when controls without BT diseases were used. In two studies, no Helicobacter species were detected in either cases or controls. Helicobacter species were also often detected in benign BT diseases such as gallstone disease or chronic cholecystitis. As our current knowledge relies on a few small studies that showed substantial differences, larger studies and more standardised protocols for detecting DNA and antibodies against Helicobacter species are needed to investigate a potential association with BT cancer.
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