Congenital anomalies associated with oil and gas development and resource extraction: a population-based retrospective cohort study in Texas.
Congenital anomalies associated with oil and gas development and resource extraction: a population-based retrospective cohort study in Texas.
复制标题
DOI：
10.1038/s41370-022-00505-x
复制
发表时间：
2023-01
影响因子：
4.5
通讯作者：
Hystad, Perry
中科院分区：
文献类型：
--
作者：
Willis, Mary D.;Carozza, Susan E.;Hystad, Perry
与石油和天然气开采有关的活动造成空气和水污染，其中含有已知和可疑的致畸物。迄今为止，子宫内接触这些活动对健康的影响基本上是未知的。我们调查了德克萨斯州（石油和天然气的最大生产国之一）子宫内暴露于石油和天然气开采活动与先天性异常之间的关联。我们在1999年至2009年期间创建了一个基于人口的出生队列，其中包含分娩时的完整产妇地址，并与全州先天性异常监测系统相关联（n= 2，234，138例出生，86，315例）。我们使用距离平方倒数加权的三分位数在5公里内检查了与开采相关的暴露，包括钻井现场计数、天然气生产、石油生产和采出水。在调整后的逻辑回归模型中，我们使用两个比较组计算了任何先天性异常和10个特定器官部位的几率：1）5公里尚未运行的未来钻探部位（先验主要模型），以及2）5-10公里的活动井。使用时间比较组，我们发现在部位计数的最高三分位暴露组中任何先天性异常的几率增加（OR：1.25; 95% CI：1.21，1.30），产油量（OR：1.08; 95%CI：1.04，1.12）、产气量（1.20; 95%CI：1.17，1.23）和采出水（OR：1.17; 95%CI：1.14，1.20）。然而，在三分位数中，相关性并不遵循一致的假设-反应模式。相关性高度减弱，但仍在增加，空间比较组处于最高三分位暴露组。心脏和循环缺陷与所有暴露指标密切相关。在这项基于大规模人群的研究中，先天性异常，特别是心脏和循环缺陷的几率增加与石油和天然气开采相关的暴露有关。未来的研究需要确认研究结果，检查具体的接触途径，并确定潜在的途径，以减少当地人口的接触。
Oil and gas extraction-related activities produce air and water pollution that contains known and suspected teratogens. To date, health impacts of in utero exposure to these activities is largely unknown. We investigated associations between in utero exposure to oil and gas extraction activity in Texas, one of the highest producers of oil and gas, and congenital anomalies. We created a population-based birth cohort between 1999 and 2009 with full maternal address at delivery and linked to the statewide congenital anomaly surveillance system (n=2,234,138 births, 86,315 cases). We examined extraction-related exposures using tertiles of inverse distance-squared weighting within 5 km for drilling site count, gas production, oil production, and produced water. In adjusted logistic regression models, we calculated odds of any congenital anomaly and 10 specific organ sites using two comparison groups: 1) 5 km of future drilling sites that are not yet operating (a priori main models), and 2) 5–10 km of an active well. Using the temporal comparison group, we find increased odds of any congenital anomaly in the highest tertile exposure group for site count (OR: 1.25; 95% CI: 1.21, 1.30), oil production (OR: 1.08; 95% CI: 1.04, 1.12), gas production (1.20; 95% CI: 1.17, 1.23), and produced water (OR: 1.17; 95% CI: 1.14, 1.20). However, associations did not follow a consistent exposure-response pattern across tertiles. Associations are highly attenuated, but still increased, with the spatial comparison group in the highest tertile exposure group. Cardiac and circulatory defects are strongly and consistently associated with all exposure metrics. Increased odds of congenital anomalies, particularly cardiac and circulatory defects, were associated with exposures related to oil and gas extraction in this large population-based study. Future research is needed to confirm findings, examine specific exposure pathways, and identify potential avenues to reduce exposures among local populations.
登录
查看更多内容
影响因子：
3.3
作者：
Boulet, Sheree L.;Shin, Mikyong;Correa, Adolfo
通讯作者：
Correa, Adolfo
影响因子：
7.9
作者：
Deziel, Nicole C.;Clark, Cassandra J.;Casey, Joan A.;Bell, Michelle L.;Plata, Desiree L.;Saiers, James E.
通讯作者：
Saiers, James E.
影响因子：
4.3
作者：
Colborn, Theo;Schultz, Kim;Kwiatkowski, Carol
通讯作者：
Kwiatkowski, Carol
影响因子：
10.4
作者：
Deziel NC
通讯作者：
Deziel NC
影响因子：
13.6
作者：
Currie J;Greenstone M;Meckel K
通讯作者：
Meckel K