<i>Montipora digitata</i> Exoskeleton Derived Aragonite Particles are useful Scaffold for Tissue-engineered Vascular Graft <i>in Vitro</i>
<i>Montipora digitata</i> Exoskeleton Derived Aragonite Particles are useful Scaffold for Tissue-engineered Vascular Graft <i>in Vitro</i>
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<i>Montipora digitalata</i>外骨骼衍生文石颗粒可作为组织工程血管移植物<i>体外</i>的有用支架
DOI：
10.11344/nano.9.105
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Tanaka A
中科院分区：
文献类型：
--
作者：
Okamura T;Uemura N;Baba S;Yasuda N;Yamashiro H;Imai K;Nishikawa T;Shimizu H;Shida M;Tominaga K;Tanaka A
设计与宿主免疫相容的术前组织工程血管移植物（TEVG）是血管组织工程的目标之一。血管生成是伤口愈合的重要早期步骤，使用支架的毛细血管的三维形成极大地有助于骨再生治疗的成功。本研究以指状单孔珊瑚（Montipora digitata，一种硬珊瑚）外骨骼中的文石颗粒为支架材料，应用于正常人皮肤成纤维细胞和正常人脐带静脉内皮细胞的三维培养，并从形态学上观察其效果。结果，该颗粒在体外三维地促进细胞增殖和毛细血管分化。此外，观察到来自文石颗粒的钙掺入共培养的正常人真皮皮肤成纤维细胞和正常人脐静脉内皮细胞。因此，文石颗粒被推断是一个有用的支架三维毛细血管培养。
Designing a preoperative tissue engineering vascular graft (TEVG) that is immunologically compatible with the host is one of the goals of vascular tissue engineering. Angiogenesis is an important early step in wound healing, and the three-dimensional formation of capillaries using scaffold contributes greatly to the success of bone regeneration therapy. In this study, aragonite particles derived from exoskeleton of Montipora digitata (a kind of hard coral) as a scaffold of TEVG were applied to three-dimensional culture of normal human dermal skin fibroblasts and normal human umbilical cord vein endothelial cells, and the effect was observed morphologically. As a result, the particles promoted cell proliferation and capillary differentiation three-dimensionally in vitro. Also, incorporation of calcium from the aragonite particles into co-cultured normal human dermal skin fibroblasts and normal human umbilical vein endothelial cells was observed. Thus, aragonite particles were inferred to be a useful scaffold for 3 dimensional capillary culture.
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