Low plasma eicosapentaenoic acid levels are associated with elevated trait aggression and impulsivity in major depressive disorder with a history of comorbid substance use disorder.
Low plasma eicosapentaenoic acid levels are associated with elevated trait aggression and impulsivity in major depressive disorder with a history of comorbid substance use disorder.
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DOI：
10.1016/j.jpsychires.2014.06.012
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发表时间：
2014-10
影响因子：
4.8
通讯作者：
Sublette, M. Elizabeth
中科院分区：
文献类型：
--
作者：
Beier, Anne Mette;Lauritzen, Lotte;Galfalvy, Hanga C.;Cooper, Thomas B.;Oquendo, Maria A.;Grunebaum, Michael F.;Mann, J. John;Sublette, M. Elizabeth
重度抑郁症 (MDD) 与低水平的 omega-3 多不饱和脂肪酸 (PUFA) 有关，这有望为疾病病因学和治疗目标提供新的视角。由于在某些临床情况下，攻击性和冲动行为与低 omega-3 PUFA 水平相关，因此我们研究了 MDD 患者的血浆 PUFA 与攻击性和冲动性特征的关系。使用布朗-古德温攻击量表对未接受药物治疗的 MDD 患者 (n=48) 和健康志愿者 (HV, n=35) 进行评估。一个子集（MDD，n=39；HV，n=33）完成了 Barratt 冲动量表。对血浆 PUFA 二十碳五烯酸 (EPA, 20:5n-3)、二十二碳六烯酸 (DHA, 22:6n-3) 和花生四烯酸 (AA, 20:4n-6) 进行定量和 ln 转化，以减轻分布偏差。 Ln 转化的 PUFA (lnPUFA) 水平是回归模型中的预测因子，以攻击性或冲动评分作为结果，以及性别和诊断状态（有或没有物质使用障碍 [SUD] 或 HV 病史的 MDD）的辅助因素。测试了相关 PUFA 和诊断状态之间的相互作用。其他分析探讨了抑郁症严重程度、自我报告的童年虐待史以及重度抑郁症患者的自杀企图史之间可能存在的混淆。在PUFA中，lnEPA而非lnDHA预测攻击性（F1,76=12.493，p=0.001）和冲动性（F1,65=5.598，p=0.021），lnEPA和SUD历史之间的交互作用对于攻击性（F1,76=7.941，p=0.001）和冲动性（F1,65=3.485，p=0.037）。当根据童年虐待、抑郁严重程度或自杀未遂史进行调整后，结果仍然显着。总之，低 EPA 水平仅在 MDD 和共病 SUD 患者中与攻击性和冲动相关，即使在大多数情况下 SUD 处于完全持续缓解状态。
Major depressive disorder (MDD) is associated with low levels of omega-3 polyunsaturated fatty acids (PUFAs), holding promise for new perspectives on disease etiology and treatment targets. As aggressive and impulsive behaviors are associated with low omega-3 PUFA levels in some clinical contexts, we investigated plasma PUFA relationships with trait aggression and impulsivity in patients with MDD. Medication-free MDD patients (n=48) and healthy volunteers (HV, n=35) were assessed with the Brown-Goodwin Aggression Inventory. A subset (MDD, n=39; HV, n=33) completed the Barratt Impulsiveness Scale. Plasma PUFAs eicosapentaenoic acid (EPA, 20:5n-3), docosahexaenoic acid (DHA, 22:6n-3), and arachidonic acid (AA, 20:4n-6) were quantified and ln-transformed to mitigate distributional skew. Ln-transformed PUFA (lnPUFA) levels were predictors in regression models, with aggression or impulsivity scores as outcomes, and cofactors of sex and diagnostic status (MDD with or without a history of substance use disorder [SUD], or HV). Interactions were tested between relevant PUFAs and diagnostic status. Additional analyses explored possible confounds of depression severity, self-reported childhood abuse history, and, in MDD patients, suicide attempt history. Among PUFA, lnEPA but not lnDHA predicted aggression (F1,76=12.493, p=0.001), and impulsivity (F1,65=5.598, p=0.021), with interactions between lnEPA and history of SUD for both aggression (F1,76=7.941, p=0.001) and impulsivity (F1,65=3.485, p=0.037). Results remained significant when adjusted for childhood abuse, depression severity, or history of suicide attempt. In conclusion, low EPA levels were associated with aggression and impulsivity only in patients with MDD and comorbid SUD, even though in most cases SUD was in full sustained remission.
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影响因子：
11.3
作者：
Buydens-Branchey, Laure;Branchey, Marc
通讯作者：
Branchey, Marc
影响因子：
5.6
作者：
Bhattacharya, Arunabh;Sun, Dongxu;Fernandes, Gabriel
通讯作者：
Fernandes, Gabriel
DOI：
10.1016/j.plefa.2009.01.005
发表时间：
2009-02-01
影响因子：
3
作者：
Chen, Chuck T.;Liu, Zhen;Bazinet, Richard P.
通讯作者：
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影响因子：
3.6
作者：
Barnow, S;Lucht, M;Freyberger, HJ
通讯作者：
Freyberger, HJ
影响因子：
4.2
作者：
Buydens-Branchey, L;Branchey, M;Hibbeln, JR
通讯作者：
Hibbeln, JR